Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)
| signature | var | Other | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|---|
| all | param | scale = 0.138, shape = 1.05 | scale = 0.102, shape = 1.05 | scale = 0.103, shape = 1.05 | scale = 0.11, shape = 1.05 | scale = 0.11, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 9.6, median = 6.9 | mean = 9.5, median = 6.8 | mean = 8.9, median = 6.4 | mean = 8.9, median = 6.4 | |
| effect | af = 1, hr = 1 | af = 1.35, hr = 0.73 | af = 1.34, hr = 0.74 | af = 1.25, hr = 0.79 | af = 1.25, hr = 0.79 | |
| TP53- & AR- | param | scale = 0.138, shape = 1.05 | scale = 0.048, shape = 1.05 | scale = 0.114, shape = 1.05 | scale = 0.113, shape = 1.05 | scale = 0.113, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 20.5, median = 14.8 | mean = 8.6, median = 6.2 | mean = 8.7, median = 6.2 | mean = 8.7, median = 6.2 | |
| effect | af = 1, hr = 1 | af = 2.89, hr = 0.33 | af = 1.21, hr = 0.82 | af = 1.22, hr = 0.81 | af = 1.22, hr = 0.81 | |
| TP53+ | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.095, shape = 1.05 | scale = 0.111, shape = 1.05 | scale = 0.111, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 10.3, median = 7.4 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.45, hr = 0.68 | af = 1.24, hr = 0.8 | af = 1.24, hr = 0.8 | |
| HRD+ | param | scale = 0.138, shape = 1.05 | scale = 0.116, shape = 1.05 | scale = 0.095, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 8.5, median = 6.1 | mean = 10.3, median = 7.4 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | |
| effect | af = 1, hr = 1 | af = 1.19, hr = 0.83 | af = 1.45, hr = 0.68 | af = 3.86, hr = 0.24 | af = 3.86, hr = 0.24 | |
| TEfus+ | param | scale = 0.138, shape = 1.05 | scale = 0.118, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.1, shape = 1.05 | scale = 0.1, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 8.3, median = 6 | mean = 23.5, median = 16.9 | mean = 9.8, median = 7.1 | mean = 9.8, median = 7.1 | |
| effect | af = 1, hr = 1 | af = 1.17, hr = 0.85 | af = 3.31, hr = 0.28 | af = 1.38, hr = 0.71 | af = 1.38, hr = 0.71 |
| subtype | var | Other | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.138, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 27.4, median = 19.7 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | |
| effect | af = 1, hr = 1 | af = 3.86, hr = 0.24 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.138, shape = 1.05 | scale = 0.05, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 19.4, median = 14 | mean = 27.4, median = 19.7 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | |
| effect | af = 1, hr = 1 | af = 2.73, hr = 0.35 | af = 3.86, hr = 0.24 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 27.4, median = 19.7 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.86, hr = 0.24 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.138, shape = 1.05 | scale = 0.076, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 12.9, median = 9.3 | mean = 7.1, median = 5.1 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | |
| effect | af = 1, hr = 1 | af = 1.82, hr = 0.53 | af = 1, hr = 1 | af = 3.86, hr = 0.24 | af = 3.86, hr = 0.24 | |
| -+-+ | param | scale = 0.138, shape = 1.05 | scale = 0.076, shape = 1.05 | scale = 0.047, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 12.9, median = 9.3 | mean = 21, median = 15.1 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | |
| effect | af = 1, hr = 1 | af = 1.82, hr = 0.53 | af = 2.96, hr = 0.32 | af = 3.86, hr = 0.24 | af = 3.86, hr = 0.24 | |
| -++- | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.86, hr = 0.24 | af = 3.86, hr = 0.24 | |
| -+++ | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.047, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 21, median = 15.1 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.96, hr = 0.32 | af = 3.86, hr = 0.24 | af = 3.86, hr = 0.24 | |
| +— | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 27.4, median = 19.7 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.86, hr = 0.24 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 27.4, median = 19.7 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.86, hr = 0.24 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.86, hr = 0.24 | af = 3.86, hr = 0.24 | |
| ++-+ | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.39, hr = 0.4 | af = 3.86, hr = 0.24 | af = 3.86, hr = 0.24 | |
| +++- | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.86, hr = 0.24 | af = 3.86, hr = 0.24 | |
| ++++ | param | scale = 0.138, shape = 1.05 | scale = 0.138, shape = 1.05 | scale = 0.058, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 |
| summary | mean = 7.1, median = 5.1 | mean = 7.1, median = 5.1 | mean = 17, median = 12.2 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 2.39, hr = 0.4 | af = 3.86, hr = 0.24 | af = 3.86, hr = 0.24 |
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The overall error was 0.044.
The corresponding errors separate for the different treatments were:
ARSi Taxane_CT Platinum_CT PARPi
0.010 0.016 0.008 0.012
The overall power was 0.79.
The corresponding power separate for the different treatments were:
ARSi Taxane_CT Platinum_CT PARPi
0.218 0.222 0.440 0.390
| signature | var | Control | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 4 | 0 | 0 | 1 |
| futility | 0 | 0 | 1 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 268 (236, 306) | 192 (132, 253) | 242 (178, 285) | 243 (190, 284) | 240 (190, 283) | |
| n_unique | 247 (217, 280) | 176 (119, 232) | 222 (163, 261) | 224 (175, 260) | 221 (174, 261) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 5 (4, 6) | 3 (3, 3) | NA (NA, NA) | 4 (4, 4) | |
| post_p | NA (NA, NA) | 0.83 (0.23, 1) | 0.84 (0.24, 0.99) | 0.56 (0.1, 0.93) | 0.56 (0.09, 0.93) | |
| rate | 0.095 (0.086, 0.105) | 0.084 (0.072, 0.1) | 0.085 (0.076, 0.099) | 0.093 (0.083, 0.105) | 0.093 (0.083, 0.105) | |
| TP53- & AR- | graduation | 0 | 109 | 3 | 5 | 3 |
| futility | 0 | 1 | 89 | 51 | 72 | |
| max_n | 0 | 3 | 5 | 7 | 4 | |
| n | 108 (89, 134) | 86 (27, 111) | 97 (32, 120) | 96 (52, 123) | 95 (40, 122) | |
| n_unique | 99 (81, 124) | 80 (25, 103) | 89 (30, 112) | 90 (49, 112) | 88 (38, 112) | |
| time_trial | 36 (36, 36) | 36 (11, 36) | 36 (13, 36) | 36 (18, 36) | 36 (15, 36) | |
| time_stop | NA (NA, NA) | 11 (8, 19) | 13 (8, 21) | 12 (9, 18) | 13 (9, 19) | |
| post_p | NA (NA, NA) | 1 (0.96, 1) | 0.07 (0, 0.41) | 0.11 (0, 0.49) | 0.09 (0, 0.49) | |
| rate | 0.077 (0.065, 0.089) | 0.043 (0.036, 0.053) | 0.1 (0.083, 0.123) | 0.096 (0.081, 0.118) | 0.098 (0.081, 0.119) | |
| TP53+ | graduation | 0 | 1 | 18 | 3 | 4 |
| futility | 0 | 219 | 0 | 0 | 3 | |
| max_n | 0 | 0 | 12 | 10 | 13 | |
| n | 119 (101, 140) | 86 (30, 115) | 110 (81, 134) | 111 (90, 131) | 110 (89, 135) | |
| n_unique | 109 (92, 129) | 78 (28, 105) | 100 (74, 123) | 102 (83, 120) | 102 (82, 124) | |
| time_trial | 36 (36, 36) | 36 (11, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 18 (9, 31) | 13 (10, 17) | 12 (9, 14) | 11 (9, 14) | |
| post_p | NA (NA, NA) | 0.05 (0, 0.31) | 0.99 (0.74, 1) | 0.78 (0.34, 0.98) | 0.83 (0.35, 0.99) | |
| rate | 0.112 (0.097, 0.127) | 0.143 (0.122, 0.175) | 0.078 (0.064, 0.096) | 0.096 (0.082, 0.113) | 0.095 (0.081, 0.113) | |
| HRD+ | graduation | 0 | 0 | 0 | 220 | 195 |
| futility | 0 | 220 | 32 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 81 (68, 100) | 48 (27, 77) | 71 (45, 96) | 67 (28, 89) | 69 (29, 89) | |
| n_unique | 75 (62, 93) | 43 (24, 69) | 64 (40, 87) | 60 (26, 82) | 62 (27, 80) | |
| time_trial | 36 (36, 36) | 36 (17, 36) | 36 (36, 36) | 36 (16, 36) | 36 (17, 36) | |
| time_stop | NA (NA, NA) | 22 (14, 32) | 18 (12, 27) | 22 (14, 34) | 23 (14, 34) | |
| post_p | NA (NA, NA) | 0.18 (0.02, 0.6) | 0.69 (0.22, 0.96) | 1 (1, 1) | 1 (1, 1) | |
| rate | 0.103 (0.087, 0.123) | 0.113 (0.089, 0.143) | 0.083 (0.067, 0.105) | 0.035 (0.027, 0.044) | 0.035 (0.027, 0.045) | |
| TEfus+ | graduation | 0 | 0 | 111 | 2 | 2 |
| futility | 0 | 155 | 0 | 4 | 10 | |
| max_n | 0 | 0 | 1 | 0 | 3 | |
| n | 104 (86, 121) | 66 (32, 98) | 91 (34, 112) | 92 (71, 115) | 91 (67, 114) | |
| n_unique | 95 (79, 111) | 60 (29, 90) | 82 (31, 102) | 84 (63, 105) | 83 (61, 105) | |
| time_trial | 36 (36, 36) | 36 (16, 36) | 36 (15, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 20 (11, 31) | 16 (10, 31) | 12 (8, 14) | 16 (9, 26) | |
| post_p | NA (NA, NA) | 0.04 (0, 0.3) | 1 (0.98, 1) | 0.37 (0.06, 0.84) | 0.39 (0.07, 0.82) | |
| rate | 0.08 (0.067, 0.095) | 0.111 (0.091, 0.137) | 0.04 (0.032, 0.049) | 0.083 (0.069, 0.102) | 0.082 (0.069, 0.099) |
| subtype | var | Control | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 114 | 93 | 56 | 76 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 3 | 5 | 7 | 4 | |
| n | 64 (50, 83) | 56 (19, 71) | 58 (21, 75) | 60 (35, 76) | 59 (24, 75) | |
| n_unique | 58 (45, 77) | 53 (17, 68) | 54 (20, 70) | 57 (32, 72) | 55 (23, 71) | |
| post_p | NA (NA, NA) | 1 (0.99, 1) | 0.01 (0, 0.08) | 0.01 (0, 0.1) | 0 (0, 0.09) | |
| rate | 0.078 (0.061, 0.097) | 0.034 (0.027, 0.045) | 0.141 (0.116, 0.172) | 0.139 (0.116, 0.166) | 0.141 (0.116, 0.171) | |
| —+ | graduation | 0 | 241 | 195 | 62 | 85 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 3 | 6 | 7 | 7 | |
| n | 14 (9, 20) | 9 (3, 16) | 11 (3, 18) | 13 (5, 19) | 13 (4, 19) | |
| n_unique | 12 (8, 19) | 8 (2, 15) | 10 (2, 16) | 12 (5, 18) | 11 (4, 18) | |
| post_p | NA (NA, NA) | 0.68 (0.36, 0.93) | 0.84 (0.52, 0.98) | 0.08 (0.01, 0.31) | 0.09 (0.01, 0.32) | |
| rate | 0.056 (0.035, 0.09) | 0.051 (0.028, 0.097) | 0.038 (0.018, 0.069) | 0.144 (0.097, 0.237) | 0.144 (0.095, 0.232) | |
| –+- | graduation | 0 | 224 | 19 | 3 | 8 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 12 | 10 | 13 | |
| n | 37 (28, 47) | 31 (10, 40) | 36 (28, 45) | 37 (29, 45) | 37 (28, 46) | |
| n_unique | 34 (26, 43) | 28 (10, 38) | 34 (25, 42) | 34 (26, 42) | 34 (25, 43) | |
| post_p | NA (NA, NA) | 0.48 (0.13, 0.85) | 0.52 (0.13, 0.89) | 0.49 (0.11, 0.87) | 0.53 (0.14, 0.86) | |
| rate | 0.139 (0.111, 0.178) | 0.143 (0.113, 0.2) | 0.14 (0.107, 0.176) | 0.142 (0.113, 0.18) | 0.14 (0.112, 0.179) | |
| –++ | graduation | 0 | 296 | 118 | 8 | 18 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 13 | 10 | 13 | |
| n | 26 (19, 34) | 17 (6, 27) | 23 (9, 32) | 26 (19, 34) | 25 (18, 34) | |
| n_unique | 23 (17, 32) | 16 (5, 25) | 21 (8, 29) | 24 (17, 32) | 23 (16, 31) | |
| post_p | NA (NA, NA) | 0.12 (0.02, 0.4) | 0.99 (0.91, 1) | 0.08 (0.01, 0.35) | 0.08 (0.01, 0.37) | |
| rate | 0.082 (0.061, 0.118) | 0.146 (0.105, 0.21) | 0.035 (0.021, 0.053) | 0.139 (0.108, 0.179) | 0.14 (0.108, 0.191) | |
| -+– | graduation | 0 | 303 | 116 | 264 | 257 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 3 | 5 | 7 | 4 | |
| n | 15 (10, 22) | 9 (3, 17) | 13 (4, 20) | 11 (4, 18) | 11 (3, 18) | |
| n_unique | 14 (9, 20) | 8 (2, 16) | 12 (4, 19) | 10 (3, 16) | 10 (3, 17) | |
| post_p | NA (NA, NA) | 0.53 (0.2, 0.85) | 0.16 (0.03, 0.42) | 0.92 (0.68, 0.99) | 0.92 (0.63, 0.99) | |
| rate | 0.107 (0.071, 0.168) | 0.078 (0.045, 0.149) | 0.142 (0.094, 0.218) | 0.036 (0.017, 0.064) | 0.036 (0.02, 0.065) | |
| -+-+ | graduation | 0 | 366 | 216 | 269 | 264 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 3 | 6 | 7 | 6 | |
| n | 15 (10, 22) | 7 (2, 17) | 12 (3, 20) | 12 (3, 19) | 11 (3, 18) | |
| n_unique | 14 (9, 21) | 7 (2, 15) | 11 (3, 18) | 11 (3, 17) | 10 (3, 17) | |
| post_p | NA (NA, NA) | 0.35 (0.1, 0.62) | 0.64 (0.31, 0.87) | 0.76 (0.46, 0.94) | 0.75 (0.43, 0.94) | |
| rate | 0.072 (0.045, 0.113) | 0.077 (0.046, 0.13) | 0.046 (0.026, 0.079) | 0.036 (0.018, 0.06) | 0.035 (0.018, 0.065) | |
| -++- | graduation | 0 | 336 | 50 | 220 | 199 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 12 | 10 | 11 | |
| n | 8 (5, 13) | 5 (1, 10) | 8 (4, 13) | 6 (2, 11) | 7 (3, 12) | |
| n_unique | 8 (4, 12) | 4 (1, 9) | 7 (3, 11) | 6 (2, 10) | 6 (2, 11) | |
| post_p | NA (NA, NA) | 0.32 (0.13, 0.57) | 0.29 (0.1, 0.58) | 0.86 (0.61, 0.98) | 0.88 (0.61, 0.98) | |
| rate | 0.143 (0.085, 0.249) | 0.156 (0.083, 0.33) | 0.144 (0.082, 0.238) | 0.034 (0.014, 0.076) | 0.036 (0.013, 0.075) | |
| -+++ | graduation | 0 | 381 | 147 | 225 | 207 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 13 | 10 | 12 | |
| n | 9 (5, 13) | 4 (1, 9) | 7 (2, 12) | 7 (3, 11) | 7 (3, 13) | |
| n_unique | 8 (4, 12) | 4 (1, 9) | 6 (2, 11) | 6 (2, 10) | 6 (2, 11) | |
| post_p | NA (NA, NA) | 0.24 (0.08, 0.42) | 0.66 (0.38, 0.88) | 0.72 (0.48, 0.91) | 0.72 (0.49, 0.92) | |
| rate | 0.095 (0.054, 0.164) | 0.152 (0.085, 0.313) | 0.044 (0.021, 0.092) | 0.035 (0.015, 0.07) | 0.037 (0.013, 0.071) | |
| +— | graduation | 0 | 4 | 1 | 0 | 1 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 12 (8, 17) | 12 (7, 16) | 12 (8, 16) | 12 (8, 16) | 12 (8, 16) | |
| n_unique | 11 (7, 16) | 11 (6, 15) | 11 (7, 15) | 11 (7, 15) | 11 (7, 15) | |
| post_p | NA (NA, NA) | 0.5 (0.17, 0.82) | 0.51 (0.19, 0.84) | 0.52 (0.18, 0.84) | 0.51 (0.16, 0.81) | |
| rate | 0.141 (0.097, 0.219) | 0.142 (0.096, 0.215) | 0.141 (0.095, 0.208) | 0.141 (0.093, 0.213) | 0.141 (0.094, 0.22) | |
| +–+ | graduation | 0 | 159 | 112 | 6 | 13 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 1 | 0 | 3 | |
| n | 10 (6, 15) | 9 (4, 13) | 9 (4, 14) | 10 (5, 15) | 10 (6, 15) | |
| n_unique | 9 (5, 14) | 8 (3, 12) | 8 (3, 13) | 9 (5, 14) | 9 (5, 14) | |
| post_p | NA (NA, NA) | 0.24 (0.07, 0.5) | 0.93 (0.72, 0.99) | 0.24 (0.05, 0.54) | 0.26 (0.06, 0.6) | |
| rate | 0.086 (0.047, 0.152) | 0.147 (0.093, 0.246) | 0.035 (0.013, 0.066) | 0.145 (0.093, 0.229) | 0.139 (0.088, 0.215) | |
| +-+- | graduation | 0 | 224 | 19 | 3 | 8 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 12 | 10 | 13 | |
| n | 10 (6, 15) | 8 (2, 12) | 10 (5, 15) | 10 (6, 14) | 10 (5, 15) | |
| n_unique | 9 (5, 13) | 7 (2, 11) | 9 (5, 13) | 9 (6, 13) | 9 (5, 13) | |
| post_p | NA (NA, NA) | 0.48 (0.21, 0.81) | 0.51 (0.21, 0.8) | 0.48 (0.2, 0.81) | 0.48 (0.18, 0.83) | |
| rate | 0.143 (0.094, 0.227) | 0.152 (0.095, 0.279) | 0.143 (0.094, 0.222) | 0.146 (0.091, 0.227) | 0.148 (0.087, 0.236) | |
| +-++ | graduation | 0 | 296 | 118 | 8 | 18 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 13 | 10 | 13 | |
| n | 11 (6, 15) | 7 (2, 12) | 9 (3, 14) | 10 (6, 15) | 10 (6, 15) | |
| n_unique | 10 (6, 14) | 6 (2, 11) | 8 (3, 13) | 9 (6, 14) | 9 (5, 14) | |
| post_p | NA (NA, NA) | 0.27 (0.08, 0.53) | 0.94 (0.72, 1) | 0.24 (0.05, 0.53) | 0.25 (0.05, 0.55) | |
| rate | 0.088 (0.048, 0.148) | 0.156 (0.094, 0.293) | 0.035 (0.016, 0.065) | 0.144 (0.094, 0.232) | 0.144 (0.091, 0.23) | |
| ++– | graduation | 0 | 224 | 33 | 220 | 196 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 8 (4, 12) | 6 (2, 11) | 8 (4, 12) | 6 (3, 11) | 6 (3, 11) | |
| n_unique | 7 (3, 11) | 5 (2, 10) | 7 (3, 12) | 6 (2, 10) | 6 (2, 10) | |
| post_p | NA (NA, NA) | 0.28 (0.1, 0.57) | 0.29 (0.1, 0.55) | 0.88 (0.64, 0.98) | 0.86 (0.63, 0.98) | |
| rate | 0.148 (0.084, 0.251) | 0.154 (0.084, 0.291) | 0.14 (0.083, 0.241) | 0.035 (0.012, 0.073) | 0.036 (0.013, 0.071) | |
| ++-+ | graduation | 0 | 304 | 142 | 225 | 206 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 1 | 0 | 2 | |
| n | 8 (5, 13) | 5 (2, 10) | 7 (2, 12) | 7 (3, 12) | 7 (2, 11) | |
| n_unique | 8 (4, 12) | 5 (1, 9) | 6 (2, 11) | 6 (2, 10) | 6 (2, 10) | |
| post_p | NA (NA, NA) | 0.24 (0.07, 0.43) | 0.59 (0.3, 0.84) | 0.77 (0.51, 0.94) | 0.77 (0.52, 0.93) | |
| rate | 0.104 (0.055, 0.185) | 0.147 (0.086, 0.305) | 0.06 (0.026, 0.114) | 0.033 (0.013, 0.07) | 0.036 (0.011, 0.069) | |
| +++- | graduation | 0 | 336 | 50 | 220 | 199 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 12 | 10 | 11 | |
| n | 8 (5, 13) | 5 (1, 9) | 8 (4, 13) | 7 (2, 11) | 7 (3, 11) | |
| n_unique | 8 (4, 12) | 4 (1, 9) | 7 (3, 11) | 6 (2, 10) | 6 (3, 10) | |
| post_p | NA (NA, NA) | 0.31 (0.11, 0.55) | 0.29 (0.1, 0.55) | 0.88 (0.63, 0.98) | 0.86 (0.63, 0.98) | |
| rate | 0.141 (0.082, 0.239) | 0.156 (0.089, 0.355) | 0.142 (0.086, 0.261) | 0.034 (0.013, 0.069) | 0.035 (0.014, 0.07) | |
| ++++ | graduation | 0 | 381 | 147 | 225 | 207 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 13 | 10 | 12 | |
| n | 9 (5, 13) | 4 (1, 10) | 7 (2, 13) | 7 (3, 12) | 7 (3, 12) | |
| n_unique | 8 (5, 12) | 4 (1, 8) | 6 (2, 11) | 6 (2, 11) | 6 (2, 11) | |
| post_p | NA (NA, NA) | 0.28 (0.09, 0.47) | 0.57 (0.3, 0.82) | 0.76 (0.5, 0.94) | 0.78 (0.5, 0.94) | |
| rate | 0.104 (0.059, 0.176) | 0.148 (0.078, 0.323) | 0.058 (0.03, 0.118) | 0.036 (0.014, 0.072) | 0.033 (0.012, 0.071) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|
| all | count | 4 | 1 | ||
| time_stop | 5 (4, 6) | 4 (4, 4) | |||
| n_trt | 32 (27, 39) | 25 (25, 25) | |||
| n_control | 34 (22, 44) | 22 (22, 22) | |||
| post_p | 0.96 (0.9, 0.98) | 0.9 (0.9, 0.9) | |||
| order | 1 (1, 1) | 1 (1, 1) | |||
| TP53- & AR- | count | 109 | 3 | 5 | 3 |
| time_stop | 11 (8, 18) | 10 (8, 10) | 9 (7, 14) | 9 (9, 17) | |
| n_trt | 27 (25, 43) | 26 (25, 28) | 30 (26, 34) | 30 (28, 38) | |
| n_control | 29 (20, 50) | 26 (16, 28) | 21 (18, 34) | 31 (25, 52) | |
| post_p | 0.97 (0.89, 1) | 0.87 (0.86, 0.96) | 0.88 (0.86, 0.91) | 0.89 (0.88, 0.96) | |
| order | 1 (1, 2) | 1 (1, 1) | 1 (1, 1.6) | 1 (1, 1.8) | |
| TP53+ | count | 1 | 18 | 3 | 4 |
| time_stop | 13 (13, 13) | 13 (10, 17) | 12 (9, 14) | 12 (11, 14) | |
| n_trt | 30 (30, 30) | 36 (27, 47) | 28 (26, 37) | 28 (26, 35) | |
| n_control | 39 (39, 39) | 38 (24, 54) | 32 (32, 46) | 38 (26, 45) | |
| post_p | 0.91 (0.91, 0.91) | 0.99 (0.94, 1) | 0.94 (0.9, 0.96) | 0.97 (0.92, 0.99) | |
| order | 1 (1, 1) | 1 (1, 2) | 2 (1.2, 2) | 2 (1.3, 2.7) | |
| HRD+ | count | 220 | 195 | ||
| time_stop | 22 (14, 34) | 23 (14, 34) | |||
| n_trt | 40 (26, 77) | 43 (26, 78) | |||
| n_control | 46 (25, 77) | 47 (26, 78) | |||
| post_p | 1 (0.98, 1) | 1 (0.98, 1) | |||
| order | 1 (1, 3) | 2 (1, 3) | |||
| TEfus+ | count | 111 | 2 | 2 | |
| time_stop | 16 (10, 31) | 12 (12, 13) | 11 (9, 13) | ||
| n_trt | 37 (25, 79) | 27 (25, 29) | 27 (26, 28) | ||
| n_control | 42 (23, 84) | 34 (28, 40) | 30 (28, 32) | ||
| post_p | 1 (0.96, 1) | 0.97 (0.96, 0.98) | 0.98 (0.96, 0.99) | ||
| order | 1 (1, 2) | 1 (1, 1) | 1 (1, 1) |
| signature | var | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|
| all | count | 1 | |||
| time_stop | 3 (3, 3) | ||||
| n_trt | 25 (25, 25) | ||||
| n_control | 20 (20, 20) | ||||
| post_p | 0.21 (0.21, 0.21) | ||||
| order | 1 (1, 1) | ||||
| TP53- & AR- | count | 1 | 89 | 51 | 72 |
| time_stop | 20 (20, 20) | 13 (9, 21) | 12 (10, 18) | 13 (9, 19) | |
| n_trt | 45 (45, 45) | 32 (26, 56) | 30 (25, 52) | 33 (25, 56) | |
| n_control | 56 (56, 56) | 35 (19, 60) | 33 (22, 47) | 33 (19, 60) | |
| post_p | 0.18 (0.18, 0.18) | 0.1 (0, 0.26) | 0.1 (0.01, 0.22) | 0.1 (0.01, 0.23) | |
| order | 3 (3, 3) | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | |
| TP53+ | count | 219 | 3 | ||
| time_stop | 18 (9, 31) | 9 (8, 13) | |||
| n_trt | 51 (27, 90) | 26 (25, 42) | |||
| n_control | 51 (23, 97) | 22 (20, 40) | |||
| post_p | 0.05 (0.01, 0.18) | 0.15 (0.12, 0.17) | |||
| order | 1 (1, 3) | 1 (1, 1.8) | |||
| HRD+ | count | 220 | 32 | ||
| time_stop | 22 (14, 32) | 18 (12, 27) | |||
| n_trt | 36 (25, 57) | 32 (26, 59) | |||
| n_control | 42 (24, 66) | 36 (21, 57) | |||
| post_p | 0.07 (0.01, 0.22) | 0.11 (0.02, 0.26) | |||
| order | 2 (1, 3) | 2 (1, 3) | |||
| TEfus+ | count | 155 | 4 | 10 | |
| time_stop | 20 (11, 31) | 10 (8, 14) | 19 (12, 26) | ||
| n_trt | 43 (26, 70) | 30 (27, 31) | 39 (27, 56) | ||
| n_control | 50 (26, 87) | 24 (21, 30) | 52 (27, 73) | ||
| post_p | 0.03 (0, 0.14) | 0.1 (0.05, 0.15) | 0.08 (0.04, 0.16) | ||
| order | 2 (1, 3) | 2 (1.3, 2) | 2 (1, 2.1) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | ARSi | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| time | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | ||
| n | 10 (8, 12) | 1 (1, 1) | 5 (3, 7) | 4 (2, 5) | 2 (1, 3) | 2 (1, 4) | 0 (0, 1) | 0 (0, 1) | 2 (2, 3) | 0 (0, 2) | 0 (0, 1) | 1 (0, 2) | 1 (0, 1) | 1 (0, 2) | 0 (0, 2) | 0 (0, 1) | ||
| post_p | 0.7 (0.58, 0.79) | 0.53 (0.52, 0.55) | 0.69 (0.61, 0.71) | 0.58 (0.55, 0.77) | 0.54 (0.54, 0.54) | 0.53 (0.51, 0.53) | NA (NA, NA) | 0.54 (0.54, 0.54) | 0.54 (0.52, 0.62) | 0.54 (0.54, 0.54) | 0.5 (0.5, 0.5) | 0.54 (0.52, 0.56) | 0.5 (0.5, 0.5) | 0.51 (0.51, 0.52) | 0.53 (0.53, 0.53) | 0.51 (0.51, 0.51) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.012 (0, 0.041) | 0 (0, 0) | 0.079 (0.021, 0.112) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.112) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.578) | 0 (0, 0.471) | 0.395 (0.079, 0.712) | 0 (0, 0) | ||
| PARPi | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | ||
| n | 5 (5, 5) | 2 (2, 2) | 6 (6, 6) | 1 (1, 1) | 1 (1, 1) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 5 (5, 5) | 1 (1, 1) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.59 (0.59, 0.59) | 0.51 (0.51, 0.51) | 0.5 (0.5, 0.5) | 0.53 (0.53, 0.53) | 0.53 (0.53, 0.53) | 0.54 (0.54, 0.54) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.57 (0.57, 0.57) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.58 (0.58, 0.58) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.085 (0.085, 0.085) | 0 (0, 0) | 0.151 (0.151, 0.151) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||
| TP53- & AR- | ARSi | count | 109 | 109 | 109 | 109 | ||||||||||||
| time | 11 (8, 18) | 11 (8, 18) | 11 (8, 18) | 11 (8, 18) | ||||||||||||||
| n | 19 (15, 30) | 4 (1, 8) | 3 (1, 6) | 3 (1, 5) | ||||||||||||||
| post_p | 0.96 (0.84, 1) | 0.59 (0.52, 0.76) | 0.6 (0.51, 0.75) | 0.54 (0.51, 0.61) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.027 (0.011, 0.05) | 0.019 (0, 0.074) | 0 (0, 0.08) | 0 (0, 0.078) | ||||||||||||||
| Taxane_CT | count | 3 | 3 | 3 | 3 | |||||||||||||
| time | 10 (8, 10) | 10 (8, 10) | 10 (8, 10) | 10 (8, 10) | ||||||||||||||
| n | 19 (13, 20) | 3 (1, 5) | 3 (1, 5) | 4 (2, 5) | ||||||||||||||
| post_p | 0.84 (0.79, 0.84) | 0.65 (0.56, 0.69) | 0.53 (0.51, 0.68) | 0.56 (0.54, 0.56) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.047 (0.033, 0.079) | 0 (0, 0) | 0 (0, 0.077) | 0 (0, 0) | ||||||||||||||
| Platinum_CT | count | 5 | 5 | 5 | 5 | |||||||||||||
| time | 9 (7, 14) | 9 (7, 14) | 9 (7, 14) | 9 (7, 14) | ||||||||||||||
| n | 21 (15, 25) | 3 (2, 4) | 4 (2, 5) | 3 (1, 4) | ||||||||||||||
| post_p | 0.77 (0.74, 0.84) | 0.57 (0.52, 0.63) | 0.59 (0.54, 0.69) | 0.56 (0.52, 0.66) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.079 (0.072, 0.087) | 0.048 (0, 0.055) | 0 (0, 0) | 0 (0, 0.014) | ||||||||||||||
| PARPi | count | 3 | 3 | 3 | 3 | |||||||||||||
| time | 9 (9, 17) | 9 (9, 17) | 9 (9, 17) | 9 (9, 17) | ||||||||||||||
| n | 21 (18, 22) | 3 (2, 4) | 3 (1, 8) | 5 (3, 7) | ||||||||||||||
| post_p | 0.76 (0.73, 0.8) | 0.58 (0.54, 0.58) | 0.54 (0.53, 0.79) | 0.58 (0.57, 0.7) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.095 (0.077, 0.096) | 0 (0, 0.14) | 0 (0, 0.01) | 0 (0, 0.037) | ||||||||||||||
| TP53+ | ARSi | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | ||||||||||
| n | 17 (17, 17) | 5 (5, 5) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 4 (4, 4) | 1 (1, 1) | 0 (0, 0) | ||||||||||
| post_p | 0.81 (0.81, 0.81) | 0.57 (0.57, 0.57) | 0.56 (0.56, 0.56) | 0.54 (0.54, 0.54) | 0.52 (0.52, 0.52) | 0.62 (0.62, 0.62) | 0.56 (0.56, 0.56) | NA (NA, NA) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.072 (0.072, 0.072) | 0.059 (0.059, 0.059) | 0 (0, 0) | 0 (0, 0) | 0.151 (0.151, 0.151) | 0.07 (0.07, 0.07) | 0 (0, 0) | NA (NA, NA) | ||||||||||
| Taxane_CT | count | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | |||||||||
| time | 13 (10, 17) | 13 (10, 17) | 13 (10, 17) | 13 (10, 17) | 13 (10, 17) | 13 (10, 17) | 13 (10, 17) | 13 (10, 17) | ||||||||||
| n | 12 (8, 16) | 8 (5, 11) | 2 (1, 4) | 2 (0, 4) | 4 (0, 7) | 4 (2, 7) | 2 (0, 4) | 4 (0, 5) | ||||||||||
| post_p | 0.8 (0.71, 0.9) | 0.88 (0.73, 0.93) | 0.54 (0.51, 0.59) | 0.57 (0.52, 0.69) | 0.64 (0.54, 0.77) | 0.75 (0.62, 0.9) | 0.53 (0.51, 0.6) | 0.54 (0.5, 0.67) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.076 (0.052, 0.134) | 0.03 (0, 0.053) | 0.068 (0, 0.204) | 0 (0, 0.053) | 0.112 (0, 0.149) | 0 (0, 0.065) | 0.057 (0, 0.09) | 0.029 (0, 0.115) | ||||||||||
| Platinum_CT | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | ||||||||||
| n | 12 (11, 13) | 6 (5, 8) | 0 (0, 2) | 3 (2, 3) | 3 (1, 4) | 2 (0, 4) | 2 (1, 4) | 1 (1, 2) | ||||||||||
| post_p | 0.79 (0.74, 0.79) | 0.74 (0.68, 0.84) | 0.62 (0.62, 0.62) | 0.59 (0.56, 0.63) | 0.55 (0.54, 0.6) | 0.54 (0.53, 0.55) | 0.55 (0.55, 0.56) | 0.63 (0.54, 0.63) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.1 (0.081, 0.109) | 0.061 (0.047, 0.064) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.014, 0.099) | 0.067 (0.062, 0.073) | 0 (0, 0.044) | 0 (0, 0) | ||||||||||
| PARPi | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |||||||||
| time | 12 (11, 14) | 12 (11, 14) | 12 (11, 14) | 12 (11, 14) | 12 (11, 14) | 12 (11, 14) | 12 (11, 14) | 12 (11, 14) | ||||||||||
| n | 10 (8, 14) | 4 (4, 8) | 2 (1, 2) | 2 (1, 4) | 2 (1, 4) | 2 (1, 3) | 2 (1, 3) | 2 (1, 4) | ||||||||||
| post_p | 0.8 (0.73, 0.84) | 0.66 (0.57, 0.7) | 0.54 (0.51, 0.6) | 0.55 (0.51, 0.62) | 0.68 (0.65, 0.77) | 0.59 (0.57, 0.6) | 0.61 (0.54, 0.64) | 0.54 (0.51, 0.64) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.077 (0.052, 0.102) | 0.094 (0.028, 0.095) | 0 (0, 0.086) | 0.021 (0, 0.085) | 0 (0, 0.05) | 0.05 (0, 0.105) | 0 (0, 0.054) | 0 (0, 0.081) | ||||||||||
| HRD+ | Platinum_CT | count | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | ||||||||
| time | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | 22 (14, 34) | ||||||||||
| n | 8 (3, 14) | 8 (3, 15) | 4 (2, 9) | 4 (2, 10) | 4 (2, 9) | 4 (2, 9) | 4 (2, 9) | 4 (1, 10) | ||||||||||
| post_p | 0.79 (0.59, 0.97) | 0.73 (0.55, 0.89) | 0.74 (0.55, 0.95) | 0.66 (0.54, 0.85) | 0.73 (0.55, 0.94) | 0.68 (0.53, 0.89) | 0.73 (0.55, 0.93) | 0.71 (0.53, 0.89) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.03 (0, 0.06) | 0.026 (0, 0.046) | 0.029 (0, 0.077) | 0.029 (0, 0.063) | 0.028 (0, 0.081) | 0.024 (0, 0.06) | 0.027 (0, 0.063) | 0.028 (0, 0.067) | ||||||||||
| PARPi | count | 195 | 195 | 195 | 195 | 195 | 195 | 195 | 195 | |||||||||
| time | 23 (14, 34) | 23 (14, 34) | 23 (14, 34) | 23 (14, 34) | 23 (14, 34) | 23 (14, 34) | 23 (14, 34) | 23 (14, 34) | ||||||||||
| n | 8 (3, 14) | 8 (3, 17) | 4 (2, 10) | 4 (2, 9) | 4 (1, 8) | 4 (2, 10) | 5 (2, 9) | 5 (2, 10) | ||||||||||
| post_p | 0.8 (0.62, 0.97) | 0.73 (0.53, 0.89) | 0.77 (0.56, 0.95) | 0.7 (0.53, 0.89) | 0.74 (0.54, 0.94) | 0.69 (0.54, 0.85) | 0.74 (0.54, 0.93) | 0.7 (0.53, 0.9) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.027 (0, 0.059) | 0.027 (0, 0.051) | 0.029 (0, 0.068) | 0.026 (0, 0.055) | 0.027 (0, 0.083) | 0.024 (0, 0.061) | 0.03 (0, 0.067) | 0.026 (0, 0.058) | ||||||||||
| TEfus+ | Taxane_CT | count | 111 | 111 | 111 | 111 | 111 | 111 | 111 | 111 | ||||||||
| time | 16 (10, 31) | 16 (10, 31) | 16 (10, 31) | 16 (10, 31) | 16 (10, 31) | 16 (10, 31) | 16 (10, 31) | 16 (10, 31) | ||||||||||
| n | 5 (2, 12) | 10 (5, 21) | 5 (2, 13) | 3 (1, 8) | 4 (2, 9) | 4 (2, 10) | 4 (1, 8) | 3 (1, 8) | ||||||||||
| post_p | 0.71 (0.53, 0.91) | 0.91 (0.72, 1) | 0.62 (0.52, 0.84) | 0.58 (0.52, 0.79) | 0.7 (0.55, 0.95) | 0.72 (0.56, 0.95) | 0.58 (0.51, 0.8) | 0.57 (0.51, 0.77) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.028 (0, 0.061) | 0.029 (0, 0.058) | 0.027 (0, 0.057) | 0.019 (0, 0.068) | 0.023 (0, 0.074) | 0.021 (0, 0.068) | 0.026 (0, 0.064) | 0.035 (0, 0.083) | ||||||||||
| Platinum_CT | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | ||||||||||
| n | 4 (3, 5) | 8 (6, 10) | 2 (2, 3) | 3 (2, 4) | 4 (3, 4) | 2 (1, 2) | 2 (2, 3) | 2 (1, 4) | ||||||||||
| post_p | 0.67 (0.65, 0.69) | 0.63 (0.58, 0.69) | 0.56 (0.53, 0.6) | 0.59 (0.58, 0.6) | 0.62 (0.6, 0.65) | 0.57 (0.56, 0.58) | 0.74 (0.67, 0.82) | 0.62 (0.61, 0.64) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.046 (0.039, 0.054) | 0.087 (0.085, 0.09) | 0 (0, 0) | 0.022 (0.004, 0.04) | 0.037 (0.007, 0.066) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| PARPi | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | ||||||||||
| n | 2 (2, 3) | 4 (4, 5) | 6 (5, 8) | 4 (3, 4) | 3 (2, 4) | 2 (1, 2) | 4 (3, 5) | 2 (1, 2) | ||||||||||
| post_p | 0.55 (0.53, 0.57) | 0.72 (0.71, 0.72) | 0.62 (0.54, 0.69) | 0.62 (0.61, 0.63) | 0.62 (0.6, 0.64) | 0.58 (0.57, 0.59) | 0.6 (0.57, 0.63) | 0.62 (0.61, 0.62) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.054 (0.037, 0.072) | 0.053 (0.048, 0.058) | 0.045 (0.028, 0.062) | 0.028 (0.006, 0.051) | 0.036 (0.007, 0.065) | 0 (0, 0) | 0.033 (0.007, 0.06) | 0 (0, 0) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Taxane_CT | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| time | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | ||
| n | 9 (9, 9) | 1 (1, 1) | 4 (4, 4) | 1 (1, 1) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 3 (3, 3) | 1 (1, 1) | ||
| post_p | 0.49 (0.49, 0.49) | 0.5 (0.5, 0.5) | 0.38 (0.38, 0.38) | 0.47 (0.47, 0.47) | 0.43 (0.43, 0.43) | NA (NA, NA) | NA (NA, NA) | 0.49 (0.49, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.49 (0.49, 0.49) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.132 (0.132, 0.132) | 0 (0, 0) | 0.293 (0.293, 0.293) | 0 (0, 0) | 0.581 (0.581, 0.581) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.987 (0.987, 0.987) | 0.115 (0.115, 0.115) | 0 (0, 0) | ||
| TP53- & AR- | ARSi | count | 1 | 1 | 1 | 1 | ||||||||||||
| time | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | ||||||||||||||
| n | 35 (35, 35) | 3 (3, 3) | 4 (4, 4) | 3 (3, 3) | ||||||||||||||
| post_p | 0.4 (0.4, 0.4) | 0.26 (0.26, 0.26) | 0.47 (0.47, 0.47) | 0.47 (0.47, 0.47) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.068 (0.068, 0.068) | 0.191 (0.191, 0.191) | 0.106 (0.106, 0.106) | 0.09 (0.09, 0.09) | ||||||||||||||
| Taxane_CT | count | 89 | 89 | 89 | 89 | |||||||||||||
| time | 13 (9, 21) | 13 (9, 21) | 13 (9, 21) | 13 (9, 21) | ||||||||||||||
| n | 21 (16, 36) | 3 (1, 8) | 5 (2, 8) | 4 (2, 9) | ||||||||||||||
| post_p | 0.15 (0.02, 0.35) | 0.45 (0.38, 0.5) | 0.36 (0.12, 0.48) | 0.45 (0.34, 0.49) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.141 (0.107, 0.213) | 0.094 (0.058, 0.255) | 0.141 (0.071, 0.267) | 0.072 (0.038, 0.163) | ||||||||||||||
| Platinum_CT | count | 51 | 51 | 51 | 51 | |||||||||||||
| time | 12 (10, 18) | 12 (10, 18) | 12 (10, 18) | 12 (10, 18) | ||||||||||||||
| n | 20 (14, 36) | 4 (1, 9) | 4 (1, 7) | 4 (2, 8) | ||||||||||||||
| post_p | 0.18 (0.02, 0.38) | 0.36 (0.17, 0.44) | 0.46 (0.33, 0.5) | 0.44 (0.38, 0.49) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.137 (0.108, 0.198) | 0.191 (0.099, 0.409) | 0.081 (0.033, 0.239) | 0.065 (0.034, 0.219) | ||||||||||||||
| PARPi | count | 72 | 72 | 72 | 72 | |||||||||||||
| time | 13 (9, 19) | 13 (9, 19) | 13 (9, 19) | 13 (9, 19) | ||||||||||||||
| n | 22 (15, 34) | 4 (2, 8) | 4 (1, 7) | 4 (0, 8) | ||||||||||||||
| post_p | 0.19 (0.03, 0.4) | 0.36 (0.15, 0.46) | 0.46 (0.38, 0.49) | 0.45 (0.32, 0.49) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.144 (0.107, 0.206) | 0.176 (0.088, 0.357) | 0.086 (0.048, 0.193) | 0.077 (0.031, 0.22) | ||||||||||||||
| TP53+ | ARSi | count | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | ||||||||
| time | 18 (9, 31) | 18 (9, 31) | 18 (9, 31) | 18 (9, 31) | 18 (9, 31) | 18 (9, 31) | 18 (9, 31) | 18 (9, 31) | ||||||||||
| n | 17 (8, 32) | 11 (5, 22) | 3 (1, 8) | 3 (0, 6) | 5 (2, 9) | 5 (1, 9) | 3 (0, 7) | 3 (1, 7) | ||||||||||
| post_p | 0.37 (0.15, 0.49) | 0.25 (0.05, 0.47) | 0.4 (0.19, 0.48) | 0.35 (0.18, 0.47) | 0.42 (0.24, 0.48) | 0.38 (0.14, 0.48) | 0.37 (0.17, 0.48) | 0.38 (0.16, 0.48) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.163 (0.127, 0.227) | 0.152 (0.102, 0.273) | 0.172 (0.082, 0.408) | 0.164 (0.069, 0.37) | 0.182 (0.112, 0.386) | 0.167 (0.093, 0.358) | 0.166 (0.092, 0.424) | 0.167 (0.069, 0.421) | ||||||||||
| PARPi | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 9 (8, 13) | 9 (8, 13) | 9 (8, 13) | 9 (8, 13) | 9 (8, 13) | 9 (8, 13) | 9 (8, 13) | 9 (8, 13) | ||||||||||
| n | 13 (8, 17) | 9 (7, 14) | 0 (0, 0) | 0 (0, 3) | 3 (1, 5) | 3 (1, 4) | 2 (0, 3) | 1 (0, 2) | ||||||||||
| post_p | 0.28 (0.2, 0.43) | 0.23 (0.11, 0.38) | NA (NA, NA) | 0.49 (0.49, 0.49) | 0.37 (0.35, 0.39) | 0.41 (0.24, 0.47) | 0.44 (0.42, 0.47) | 0.43 (0.42, 0.45) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.211 (0.107, 0.302) | 0.112 (0.107, 0.239) | NA (NA, NA) | 0.047 (0.047, 0.047) | 0.334 (0.173, 0.496) | 0.291 (0.149, 5.074) | 0.136 (0.135, 0.137) | 0.683 (0.644, 0.722) | ||||||||||
| HRD+ | ARSi | count | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | ||||||||
| time | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | ||||||||||
| n | 8 (3, 12) | 6 (3, 12) | 4 (1, 8) | 3 (1, 7) | 4 (2, 8) | 4 (2, 8) | 4 (2, 7) | 3 (1, 7) | ||||||||||
| post_p | 0.4 (0.2, 0.48) | 0.36 (0.14, 0.46) | 0.38 (0.19, 0.47) | 0.36 (0.17, 0.46) | 0.36 (0.18, 0.48) | 0.34 (0.14, 0.46) | 0.36 (0.16, 0.48) | 0.35 (0.17, 0.46) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.101 (0.069, 0.17) | 0.085 (0.05, 0.155) | 0.165 (0.092, 0.349) | 0.157 (0.082, 0.378) | 0.16 (0.09, 0.387) | 0.159 (0.091, 0.36) | 0.173 (0.091, 0.445) | 0.159 (0.078, 0.368) | ||||||||||
| Taxane_CT | count | 32 | 32 | 32 | 32 | 32 | 32 | 32 | 32 | |||||||||
| time | 18 (12, 27) | 18 (12, 27) | 18 (12, 27) | 18 (12, 27) | 18 (12, 27) | 18 (12, 27) | 18 (12, 27) | 18 (12, 27) | ||||||||||
| n | 5 (3, 11) | 6 (3, 12) | 4 (2, 6) | 5 (1, 7) | 4 (1, 7) | 4 (2, 6) | 4 (1, 7) | 4 (2, 7) | ||||||||||
| post_p | 0.3 (0.11, 0.43) | 0.42 (0.29, 0.47) | 0.35 (0.2, 0.48) | 0.43 (0.31, 0.49) | 0.42 (0.29, 0.48) | 0.43 (0.27, 0.47) | 0.34 (0.14, 0.45) | 0.42 (0.3, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.137 (0.077, 0.285) | 0.068 (0.048, 0.107) | 0.174 (0.102, 0.324) | 0.097 (0.055, 0.301) | 0.136 (0.081, 0.217) | 0.101 (0.068, 0.248) | 0.172 (0.095, 0.573) | 0.091 (0.059, 0.19) | ||||||||||
| TEfus+ | ARSi | count | 155 | 155 | 155 | 155 | 155 | 155 | 155 | 155 | ||||||||
| time | 20 (11, 31) | 20 (11, 31) | 20 (11, 31) | 20 (11, 31) | 20 (11, 31) | 20 (11, 31) | 20 (11, 31) | 20 (11, 31) | ||||||||||
| n | 5 (2, 12) | 11 (5, 20) | 6 (2, 11) | 3 (1, 7) | 5 (2, 11) | 4 (2, 9) | 4 (1, 8) | 3 (1, 7) | ||||||||||
| post_p | 0.45 (0.31, 0.49) | 0.25 (0.05, 0.42) | 0.4 (0.24, 0.48) | 0.35 (0.2, 0.47) | 0.34 (0.15, 0.47) | 0.36 (0.14, 0.46) | 0.36 (0.15, 0.46) | 0.36 (0.19, 0.47) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.088 (0.057, 0.179) | 0.146 (0.103, 0.234) | 0.081 (0.045, 0.166) | 0.162 (0.076, 0.347) | 0.147 (0.09, 0.322) | 0.159 (0.083, 0.384) | 0.142 (0.071, 0.403) | 0.16 (0.08, 0.428) | ||||||||||
| Platinum_CT | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |||||||||
| time | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | ||||||||||
| n | 4 (3, 6) | 8 (7, 10) | 4 (3, 5) | 2 (0, 3) | 3 (3, 4) | 3 (3, 4) | 2 (2, 3) | 2 (0, 3) | ||||||||||
| post_p | 0.41 (0.23, 0.48) | 0.35 (0.32, 0.39) | 0.44 (0.4, 0.47) | 0.44 (0.38, 0.47) | 0.4 (0.37, 0.43) | 0.39 (0.34, 0.45) | 0.43 (0.4, 0.48) | 0.47 (0.46, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.203 (0.13, 0.316) | 0.135 (0.101, 0.204) | 0.063 (0.014, 0.105) | 0.132 (0.078, 0.363) | 0.237 (0.117, 0.409) | 0.201 (0.119, 0.4) | 0.161 (0.107, 0.195) | 0.07 (0.014, 0.175) | ||||||||||
| PARPi | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | |||||||||
| time | 19 (12, 26) | 19 (12, 26) | 19 (12, 26) | 19 (12, 26) | 19 (12, 26) | 19 (12, 26) | 19 (12, 26) | 19 (12, 26) | ||||||||||
| n | 6 (4, 9) | 9 (6, 15) | 4 (3, 9) | 4 (0, 6) | 6 (3, 9) | 3 (1, 7) | 4 (2, 7) | 2 (2, 8) | ||||||||||
| post_p | 0.27 (0.05, 0.42) | 0.27 (0.04, 0.44) | 0.44 (0.2, 0.48) | 0.46 (0.42, 0.49) | 0.36 (0.1, 0.41) | 0.36 (0.3, 0.43) | 0.47 (0.41, 0.49) | 0.46 (0.33, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.185 (0.082, 0.289) | 0.15 (0.109, 0.223) | 0.057 (0.027, 0.15) | 0.07 (0.02, 0.103) | 0.136 (0.122, 0.23) | 0.185 (0.148, 0.882) | 0.09 (0.04, 0.184) | 0.074 (0.026, 0.163) |