Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other ARSi Taxane_CT Platinum_CT PARPi
all param scale = 0.138, shape = 1.05 scale = 0.102, shape = 1.05 scale = 0.103, shape = 1.05 scale = 0.11, shape = 1.05 scale = 0.11, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 9.6, median = 6.9 mean = 9.5, median = 6.8 mean = 8.9, median = 6.4 mean = 8.9, median = 6.4
effect af = 1, hr = 1 af = 1.35, hr = 0.73 af = 1.34, hr = 0.74 af = 1.25, hr = 0.79 af = 1.25, hr = 0.79
TP53- & AR- param scale = 0.138, shape = 1.05 scale = 0.048, shape = 1.05 scale = 0.114, shape = 1.05 scale = 0.113, shape = 1.05 scale = 0.113, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 20.5, median = 14.8 mean = 8.6, median = 6.2 mean = 8.7, median = 6.2 mean = 8.7, median = 6.2
effect af = 1, hr = 1 af = 2.89, hr = 0.33 af = 1.21, hr = 0.82 af = 1.22, hr = 0.81 af = 1.22, hr = 0.81
TP53+ param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.095, shape = 1.05 scale = 0.111, shape = 1.05 scale = 0.111, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 10.3, median = 7.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.45, hr = 0.68 af = 1.24, hr = 0.8 af = 1.24, hr = 0.8
HRD+ param scale = 0.138, shape = 1.05 scale = 0.116, shape = 1.05 scale = 0.095, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 8.5, median = 6.1 mean = 10.3, median = 7.4 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7
effect af = 1, hr = 1 af = 1.19, hr = 0.83 af = 1.45, hr = 0.68 af = 3.86, hr = 0.24 af = 3.86, hr = 0.24
TEfus+ param scale = 0.138, shape = 1.05 scale = 0.118, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.1, shape = 1.05 scale = 0.1, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 8.3, median = 6 mean = 23.5, median = 16.9 mean = 9.8, median = 7.1 mean = 9.8, median = 7.1
effect af = 1, hr = 1 af = 1.17, hr = 0.85 af = 3.31, hr = 0.28 af = 1.38, hr = 0.71 af = 1.38, hr = 0.71



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other ARSi Taxane_CT Platinum_CT PARPi
—- param scale = 0.138, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 27.4, median = 19.7 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1
effect af = 1, hr = 1 af = 3.86, hr = 0.24 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.138, shape = 1.05 scale = 0.05, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 19.4, median = 14 mean = 27.4, median = 19.7 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1
effect af = 1, hr = 1 af = 2.73, hr = 0.35 af = 3.86, hr = 0.24 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 27.4, median = 19.7 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.86, hr = 0.24 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.138, shape = 1.05 scale = 0.076, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 12.9, median = 9.3 mean = 7.1, median = 5.1 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7
effect af = 1, hr = 1 af = 1.82, hr = 0.53 af = 1, hr = 1 af = 3.86, hr = 0.24 af = 3.86, hr = 0.24
-+-+ param scale = 0.138, shape = 1.05 scale = 0.076, shape = 1.05 scale = 0.047, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 12.9, median = 9.3 mean = 21, median = 15.1 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7
effect af = 1, hr = 1 af = 1.82, hr = 0.53 af = 2.96, hr = 0.32 af = 3.86, hr = 0.24 af = 3.86, hr = 0.24
-++- param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.86, hr = 0.24 af = 3.86, hr = 0.24
-+++ param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.047, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 21, median = 15.1 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7
effect af = 1, hr = 1 af = 1, hr = 1 af = 2.96, hr = 0.32 af = 3.86, hr = 0.24 af = 3.86, hr = 0.24
+— param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 27.4, median = 19.7 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.86, hr = 0.24 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 27.4, median = 19.7 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.86, hr = 0.24 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.86, hr = 0.24 af = 3.86, hr = 0.24
++-+ param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7
effect af = 1, hr = 1 af = 1, hr = 1 af = 2.39, hr = 0.4 af = 3.86, hr = 0.24 af = 3.86, hr = 0.24
+++- param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.86, hr = 0.24 af = 3.86, hr = 0.24
++++ param scale = 0.138, shape = 1.05 scale = 0.138, shape = 1.05 scale = 0.058, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05
summary mean = 7.1, median = 5.1 mean = 7.1, median = 5.1 mean = 17, median = 12.2 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7
effect af = 1, hr = 1 af = 1, hr = 1 af = 2.39, hr = 0.4 af = 3.86, hr = 0.24 af = 3.86, hr = 0.24

Errors and power


graduation (counts and proportions):
ARSi Taxane_CT Platinum_CT PARPi
all 4 0 0 1
TP53- & AR- 109 3 5 3
TP53+ 1 18 3 4
HRD+ 0 0 220 195
TEfus+ 0 111 2 2
ARSi Taxane_CT Platinum_CT PARPi
all 0.008 0.000 0.000 0.002
TP53- & AR- 0.218 0.006 0.010 0.006
TP53+ 0.002 0.036 0.006 0.008
HRD+ 0.000 0.000 0.440 0.390
TEfus+ 0.000 0.222 0.004 0.004
futility (counts and proportions):
ARSi Taxane_CT Platinum_CT PARPi
all 0 1 0 0
TP53- & AR- 1 89 51 72
TP53+ 219 0 0 3
HRD+ 220 32 0 0
TEfus+ 155 0 4 10
ARSi Taxane_CT Platinum_CT PARPi
all 0.000 0.002 0.000 0.000
TP53- & AR- 0.002 0.178 0.102 0.144
TP53+ 0.438 0.000 0.000 0.006
HRD+ 0.440 0.064 0.000 0.000
TEfus+ 0.310 0.000 0.008 0.020
max sample size (counts and proportions):
ARSi Taxane_CT Platinum_CT PARPi
all 0 0 0 0
TP53- & AR- 3 5 7 4
TP53+ 0 12 10 13
HRD+ 0 0 0 0
TEfus+ 0 1 0 3
ARSi Taxane_CT Platinum_CT PARPi
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.006 0.010 0.014 0.008
TP53+ 0.000 0.024 0.020 0.026
HRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.002 0.000 0.006


Errors & power

The overall error was 0.044.
The corresponding errors separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.010       0.016       0.008       0.012 

The overall power was 0.79.
The corresponding power separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.218       0.222       0.440       0.390 

Median results at the end of the trial

By signature:
signature var Control ARSi Taxane_CT Platinum_CT PARPi
all graduation 0 4 0 0 1
futility 0 0 1 0 0
max_n 0 0 0 0 0
n 268 (236, 306) 192 (132, 253) 242 (178, 285) 243 (190, 284) 240 (190, 283)
n_unique 247 (217, 280) 176 (119, 232) 222 (163, 261) 224 (175, 260) 221 (174, 261)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 5 (4, 6) 3 (3, 3) NA (NA, NA) 4 (4, 4)
post_p NA (NA, NA) 0.83 (0.23, 1) 0.84 (0.24, 0.99) 0.56 (0.1, 0.93) 0.56 (0.09, 0.93)
rate 0.095 (0.086, 0.105) 0.084 (0.072, 0.1) 0.085 (0.076, 0.099) 0.093 (0.083, 0.105) 0.093 (0.083, 0.105)
TP53- & AR- graduation 0 109 3 5 3
futility 0 1 89 51 72
max_n 0 3 5 7 4
n 108 (89, 134) 86 (27, 111) 97 (32, 120) 96 (52, 123) 95 (40, 122)
n_unique 99 (81, 124) 80 (25, 103) 89 (30, 112) 90 (49, 112) 88 (38, 112)
time_trial 36 (36, 36) 36 (11, 36) 36 (13, 36) 36 (18, 36) 36 (15, 36)
time_stop NA (NA, NA) 11 (8, 19) 13 (8, 21) 12 (9, 18) 13 (9, 19)
post_p NA (NA, NA) 1 (0.96, 1) 0.07 (0, 0.41) 0.11 (0, 0.49) 0.09 (0, 0.49)
rate 0.077 (0.065, 0.089) 0.043 (0.036, 0.053) 0.1 (0.083, 0.123) 0.096 (0.081, 0.118) 0.098 (0.081, 0.119)
TP53+ graduation 0 1 18 3 4
futility 0 219 0 0 3
max_n 0 0 12 10 13
n 119 (101, 140) 86 (30, 115) 110 (81, 134) 111 (90, 131) 110 (89, 135)
n_unique 109 (92, 129) 78 (28, 105) 100 (74, 123) 102 (83, 120) 102 (82, 124)
time_trial 36 (36, 36) 36 (11, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 18 (9, 31) 13 (10, 17) 12 (9, 14) 11 (9, 14)
post_p NA (NA, NA) 0.05 (0, 0.31) 0.99 (0.74, 1) 0.78 (0.34, 0.98) 0.83 (0.35, 0.99)
rate 0.112 (0.097, 0.127) 0.143 (0.122, 0.175) 0.078 (0.064, 0.096) 0.096 (0.082, 0.113) 0.095 (0.081, 0.113)
HRD+ graduation 0 0 0 220 195
futility 0 220 32 0 0
max_n 0 0 0 0 0
n 81 (68, 100) 48 (27, 77) 71 (45, 96) 67 (28, 89) 69 (29, 89)
n_unique 75 (62, 93) 43 (24, 69) 64 (40, 87) 60 (26, 82) 62 (27, 80)
time_trial 36 (36, 36) 36 (17, 36) 36 (36, 36) 36 (16, 36) 36 (17, 36)
time_stop NA (NA, NA) 22 (14, 32) 18 (12, 27) 22 (14, 34) 23 (14, 34)
post_p NA (NA, NA) 0.18 (0.02, 0.6) 0.69 (0.22, 0.96) 1 (1, 1) 1 (1, 1)
rate 0.103 (0.087, 0.123) 0.113 (0.089, 0.143) 0.083 (0.067, 0.105) 0.035 (0.027, 0.044) 0.035 (0.027, 0.045)
TEfus+ graduation 0 0 111 2 2
futility 0 155 0 4 10
max_n 0 0 1 0 3
n 104 (86, 121) 66 (32, 98) 91 (34, 112) 92 (71, 115) 91 (67, 114)
n_unique 95 (79, 111) 60 (29, 90) 82 (31, 102) 84 (63, 105) 83 (61, 105)
time_trial 36 (36, 36) 36 (16, 36) 36 (15, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 20 (11, 31) 16 (10, 31) 12 (8, 14) 16 (9, 26)
post_p NA (NA, NA) 0.04 (0, 0.3) 1 (0.98, 1) 0.37 (0.06, 0.84) 0.39 (0.07, 0.82)
rate 0.08 (0.067, 0.095) 0.111 (0.091, 0.137) 0.04 (0.032, 0.049) 0.083 (0.069, 0.102) 0.082 (0.069, 0.099)


By subgroup combinations:
subtype var Control ARSi Taxane_CT Platinum_CT PARPi
—- graduation 0 114 93 56 76
futility 0 0 0 0 0
max_n 0 3 5 7 4
n 64 (50, 83) 56 (19, 71) 58 (21, 75) 60 (35, 76) 59 (24, 75)
n_unique 58 (45, 77) 53 (17, 68) 54 (20, 70) 57 (32, 72) 55 (23, 71)
post_p NA (NA, NA) 1 (0.99, 1) 0.01 (0, 0.08) 0.01 (0, 0.1) 0 (0, 0.09)
rate 0.078 (0.061, 0.097) 0.034 (0.027, 0.045) 0.141 (0.116, 0.172) 0.139 (0.116, 0.166) 0.141 (0.116, 0.171)
—+ graduation 0 241 195 62 85
futility 0 0 0 0 0
max_n 0 3 6 7 7
n 14 (9, 20) 9 (3, 16) 11 (3, 18) 13 (5, 19) 13 (4, 19)
n_unique 12 (8, 19) 8 (2, 15) 10 (2, 16) 12 (5, 18) 11 (4, 18)
post_p NA (NA, NA) 0.68 (0.36, 0.93) 0.84 (0.52, 0.98) 0.08 (0.01, 0.31) 0.09 (0.01, 0.32)
rate 0.056 (0.035, 0.09) 0.051 (0.028, 0.097) 0.038 (0.018, 0.069) 0.144 (0.097, 0.237) 0.144 (0.095, 0.232)
–+- graduation 0 224 19 3 8
futility 0 0 0 0 0
max_n 0 0 12 10 13
n 37 (28, 47) 31 (10, 40) 36 (28, 45) 37 (29, 45) 37 (28, 46)
n_unique 34 (26, 43) 28 (10, 38) 34 (25, 42) 34 (26, 42) 34 (25, 43)
post_p NA (NA, NA) 0.48 (0.13, 0.85) 0.52 (0.13, 0.89) 0.49 (0.11, 0.87) 0.53 (0.14, 0.86)
rate 0.139 (0.111, 0.178) 0.143 (0.113, 0.2) 0.14 (0.107, 0.176) 0.142 (0.113, 0.18) 0.14 (0.112, 0.179)
–++ graduation 0 296 118 8 18
futility 0 0 0 0 0
max_n 0 0 13 10 13
n 26 (19, 34) 17 (6, 27) 23 (9, 32) 26 (19, 34) 25 (18, 34)
n_unique 23 (17, 32) 16 (5, 25) 21 (8, 29) 24 (17, 32) 23 (16, 31)
post_p NA (NA, NA) 0.12 (0.02, 0.4) 0.99 (0.91, 1) 0.08 (0.01, 0.35) 0.08 (0.01, 0.37)
rate 0.082 (0.061, 0.118) 0.146 (0.105, 0.21) 0.035 (0.021, 0.053) 0.139 (0.108, 0.179) 0.14 (0.108, 0.191)
-+– graduation 0 303 116 264 257
futility 0 0 0 0 0
max_n 0 3 5 7 4
n 15 (10, 22) 9 (3, 17) 13 (4, 20) 11 (4, 18) 11 (3, 18)
n_unique 14 (9, 20) 8 (2, 16) 12 (4, 19) 10 (3, 16) 10 (3, 17)
post_p NA (NA, NA) 0.53 (0.2, 0.85) 0.16 (0.03, 0.42) 0.92 (0.68, 0.99) 0.92 (0.63, 0.99)
rate 0.107 (0.071, 0.168) 0.078 (0.045, 0.149) 0.142 (0.094, 0.218) 0.036 (0.017, 0.064) 0.036 (0.02, 0.065)
-+-+ graduation 0 366 216 269 264
futility 0 0 0 0 0
max_n 0 3 6 7 6
n 15 (10, 22) 7 (2, 17) 12 (3, 20) 12 (3, 19) 11 (3, 18)
n_unique 14 (9, 21) 7 (2, 15) 11 (3, 18) 11 (3, 17) 10 (3, 17)
post_p NA (NA, NA) 0.35 (0.1, 0.62) 0.64 (0.31, 0.87) 0.76 (0.46, 0.94) 0.75 (0.43, 0.94)
rate 0.072 (0.045, 0.113) 0.077 (0.046, 0.13) 0.046 (0.026, 0.079) 0.036 (0.018, 0.06) 0.035 (0.018, 0.065)
-++- graduation 0 336 50 220 199
futility 0 0 0 0 0
max_n 0 0 12 10 11
n 8 (5, 13) 5 (1, 10) 8 (4, 13) 6 (2, 11) 7 (3, 12)
n_unique 8 (4, 12) 4 (1, 9) 7 (3, 11) 6 (2, 10) 6 (2, 11)
post_p NA (NA, NA) 0.32 (0.13, 0.57) 0.29 (0.1, 0.58) 0.86 (0.61, 0.98) 0.88 (0.61, 0.98)
rate 0.143 (0.085, 0.249) 0.156 (0.083, 0.33) 0.144 (0.082, 0.238) 0.034 (0.014, 0.076) 0.036 (0.013, 0.075)
-+++ graduation 0 381 147 225 207
futility 0 0 0 0 0
max_n 0 0 13 10 12
n 9 (5, 13) 4 (1, 9) 7 (2, 12) 7 (3, 11) 7 (3, 13)
n_unique 8 (4, 12) 4 (1, 9) 6 (2, 11) 6 (2, 10) 6 (2, 11)
post_p NA (NA, NA) 0.24 (0.08, 0.42) 0.66 (0.38, 0.88) 0.72 (0.48, 0.91) 0.72 (0.49, 0.92)
rate 0.095 (0.054, 0.164) 0.152 (0.085, 0.313) 0.044 (0.021, 0.092) 0.035 (0.015, 0.07) 0.037 (0.013, 0.071)
+— graduation 0 4 1 0 1
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (8, 17) 12 (7, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16)
n_unique 11 (7, 16) 11 (6, 15) 11 (7, 15) 11 (7, 15) 11 (7, 15)
post_p NA (NA, NA) 0.5 (0.17, 0.82) 0.51 (0.19, 0.84) 0.52 (0.18, 0.84) 0.51 (0.16, 0.81)
rate 0.141 (0.097, 0.219) 0.142 (0.096, 0.215) 0.141 (0.095, 0.208) 0.141 (0.093, 0.213) 0.141 (0.094, 0.22)
+–+ graduation 0 159 112 6 13
futility 0 0 0 0 0
max_n 0 0 1 0 3
n 10 (6, 15) 9 (4, 13) 9 (4, 14) 10 (5, 15) 10 (6, 15)
n_unique 9 (5, 14) 8 (3, 12) 8 (3, 13) 9 (5, 14) 9 (5, 14)
post_p NA (NA, NA) 0.24 (0.07, 0.5) 0.93 (0.72, 0.99) 0.24 (0.05, 0.54) 0.26 (0.06, 0.6)
rate 0.086 (0.047, 0.152) 0.147 (0.093, 0.246) 0.035 (0.013, 0.066) 0.145 (0.093, 0.229) 0.139 (0.088, 0.215)
+-+- graduation 0 224 19 3 8
futility 0 0 0 0 0
max_n 0 0 12 10 13
n 10 (6, 15) 8 (2, 12) 10 (5, 15) 10 (6, 14) 10 (5, 15)
n_unique 9 (5, 13) 7 (2, 11) 9 (5, 13) 9 (6, 13) 9 (5, 13)
post_p NA (NA, NA) 0.48 (0.21, 0.81) 0.51 (0.21, 0.8) 0.48 (0.2, 0.81) 0.48 (0.18, 0.83)
rate 0.143 (0.094, 0.227) 0.152 (0.095, 0.279) 0.143 (0.094, 0.222) 0.146 (0.091, 0.227) 0.148 (0.087, 0.236)
+-++ graduation 0 296 118 8 18
futility 0 0 0 0 0
max_n 0 0 13 10 13
n 11 (6, 15) 7 (2, 12) 9 (3, 14) 10 (6, 15) 10 (6, 15)
n_unique 10 (6, 14) 6 (2, 11) 8 (3, 13) 9 (6, 14) 9 (5, 14)
post_p NA (NA, NA) 0.27 (0.08, 0.53) 0.94 (0.72, 1) 0.24 (0.05, 0.53) 0.25 (0.05, 0.55)
rate 0.088 (0.048, 0.148) 0.156 (0.094, 0.293) 0.035 (0.016, 0.065) 0.144 (0.094, 0.232) 0.144 (0.091, 0.23)
++– graduation 0 224 33 220 196
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (4, 12) 6 (2, 11) 8 (4, 12) 6 (3, 11) 6 (3, 11)
n_unique 7 (3, 11) 5 (2, 10) 7 (3, 12) 6 (2, 10) 6 (2, 10)
post_p NA (NA, NA) 0.28 (0.1, 0.57) 0.29 (0.1, 0.55) 0.88 (0.64, 0.98) 0.86 (0.63, 0.98)
rate 0.148 (0.084, 0.251) 0.154 (0.084, 0.291) 0.14 (0.083, 0.241) 0.035 (0.012, 0.073) 0.036 (0.013, 0.071)
++-+ graduation 0 304 142 225 206
futility 0 0 0 0 0
max_n 0 0 1 0 2
n 8 (5, 13) 5 (2, 10) 7 (2, 12) 7 (3, 12) 7 (2, 11)
n_unique 8 (4, 12) 5 (1, 9) 6 (2, 11) 6 (2, 10) 6 (2, 10)
post_p NA (NA, NA) 0.24 (0.07, 0.43) 0.59 (0.3, 0.84) 0.77 (0.51, 0.94) 0.77 (0.52, 0.93)
rate 0.104 (0.055, 0.185) 0.147 (0.086, 0.305) 0.06 (0.026, 0.114) 0.033 (0.013, 0.07) 0.036 (0.011, 0.069)
+++- graduation 0 336 50 220 199
futility 0 0 0 0 0
max_n 0 0 12 10 11
n 8 (5, 13) 5 (1, 9) 8 (4, 13) 7 (2, 11) 7 (3, 11)
n_unique 8 (4, 12) 4 (1, 9) 7 (3, 11) 6 (2, 10) 6 (3, 10)
post_p NA (NA, NA) 0.31 (0.11, 0.55) 0.29 (0.1, 0.55) 0.88 (0.63, 0.98) 0.86 (0.63, 0.98)
rate 0.141 (0.082, 0.239) 0.156 (0.089, 0.355) 0.142 (0.086, 0.261) 0.034 (0.013, 0.069) 0.035 (0.014, 0.07)
++++ graduation 0 381 147 225 207
futility 0 0 0 0 0
max_n 0 0 13 10 12
n 9 (5, 13) 4 (1, 10) 7 (2, 13) 7 (3, 12) 7 (3, 12)
n_unique 8 (5, 12) 4 (1, 8) 6 (2, 11) 6 (2, 11) 6 (2, 11)
post_p NA (NA, NA) 0.28 (0.09, 0.47) 0.57 (0.3, 0.82) 0.76 (0.5, 0.94) 0.78 (0.5, 0.94)
rate 0.104 (0.059, 0.176) 0.148 (0.078, 0.323) 0.058 (0.03, 0.118) 0.036 (0.014, 0.072) 0.033 (0.012, 0.071)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var ARSi Taxane_CT Platinum_CT PARPi
all count 4 1
time_stop 5 (4, 6) 4 (4, 4)
n_trt 32 (27, 39) 25 (25, 25)
n_control 34 (22, 44) 22 (22, 22)
post_p 0.96 (0.9, 0.98) 0.9 (0.9, 0.9)
order 1 (1, 1) 1 (1, 1)
TP53- & AR- count 109 3 5 3
time_stop 11 (8, 18) 10 (8, 10) 9 (7, 14) 9 (9, 17)
n_trt 27 (25, 43) 26 (25, 28) 30 (26, 34) 30 (28, 38)
n_control 29 (20, 50) 26 (16, 28) 21 (18, 34) 31 (25, 52)
post_p 0.97 (0.89, 1) 0.87 (0.86, 0.96) 0.88 (0.86, 0.91) 0.89 (0.88, 0.96)
order 1 (1, 2) 1 (1, 1) 1 (1, 1.6) 1 (1, 1.8)
TP53+ count 1 18 3 4
time_stop 13 (13, 13) 13 (10, 17) 12 (9, 14) 12 (11, 14)
n_trt 30 (30, 30) 36 (27, 47) 28 (26, 37) 28 (26, 35)
n_control 39 (39, 39) 38 (24, 54) 32 (32, 46) 38 (26, 45)
post_p 0.91 (0.91, 0.91) 0.99 (0.94, 1) 0.94 (0.9, 0.96) 0.97 (0.92, 0.99)
order 1 (1, 1) 1 (1, 2) 2 (1.2, 2) 2 (1.3, 2.7)
HRD+ count 220 195
time_stop 22 (14, 34) 23 (14, 34)
n_trt 40 (26, 77) 43 (26, 78)
n_control 46 (25, 77) 47 (26, 78)
post_p 1 (0.98, 1) 1 (0.98, 1)
order 1 (1, 3) 2 (1, 3)
TEfus+ count 111 2 2
time_stop 16 (10, 31) 12 (12, 13) 11 (9, 13)
n_trt 37 (25, 79) 27 (25, 29) 27 (26, 28)
n_control 42 (23, 84) 34 (28, 40) 30 (28, 32)
post_p 1 (0.96, 1) 0.97 (0.96, 0.98) 0.98 (0.96, 0.99)
order 1 (1, 2) 1 (1, 1) 1 (1, 1)
Futility:
signature var ARSi Taxane_CT Platinum_CT PARPi
all count 1
time_stop 3 (3, 3)
n_trt 25 (25, 25)
n_control 20 (20, 20)
post_p 0.21 (0.21, 0.21)
order 1 (1, 1)
TP53- & AR- count 1 89 51 72
time_stop 20 (20, 20) 13 (9, 21) 12 (10, 18) 13 (9, 19)
n_trt 45 (45, 45) 32 (26, 56) 30 (25, 52) 33 (25, 56)
n_control 56 (56, 56) 35 (19, 60) 33 (22, 47) 33 (19, 60)
post_p 0.18 (0.18, 0.18) 0.1 (0, 0.26) 0.1 (0.01, 0.22) 0.1 (0.01, 0.23)
order 3 (3, 3) 1 (1, 2) 1 (1, 2) 1 (1, 2)
TP53+ count 219 3
time_stop 18 (9, 31) 9 (8, 13)
n_trt 51 (27, 90) 26 (25, 42)
n_control 51 (23, 97) 22 (20, 40)
post_p 0.05 (0.01, 0.18) 0.15 (0.12, 0.17)
order 1 (1, 3) 1 (1, 1.8)
HRD+ count 220 32
time_stop 22 (14, 32) 18 (12, 27)
n_trt 36 (25, 57) 32 (26, 59)
n_control 42 (24, 66) 36 (21, 57)
post_p 0.07 (0.01, 0.22) 0.11 (0.02, 0.26)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 155 4 10
time_stop 20 (11, 31) 10 (8, 14) 19 (12, 26)
n_trt 43 (26, 70) 30 (27, 31) 39 (27, 56)
n_control 50 (26, 87) 24 (21, 30) 52 (27, 73)
post_p 0.03 (0, 0.14) 0.1 (0.05, 0.15) 0.08 (0.04, 0.16)
order 2 (1, 3) 2 (1.3, 2) 2 (1, 2.1)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all ARSi count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6)
n 10 (8, 12) 1 (1, 1) 5 (3, 7) 4 (2, 5) 2 (1, 3) 2 (1, 4) 0 (0, 1) 0 (0, 1) 2 (2, 3) 0 (0, 2) 0 (0, 1) 1 (0, 2) 1 (0, 1) 1 (0, 2) 0 (0, 2) 0 (0, 1)
post_p 0.7 (0.58, 0.79) 0.53 (0.52, 0.55) 0.69 (0.61, 0.71) 0.58 (0.55, 0.77) 0.54 (0.54, 0.54) 0.53 (0.51, 0.53) NA (NA, NA) 0.54 (0.54, 0.54) 0.54 (0.52, 0.62) 0.54 (0.54, 0.54) 0.5 (0.5, 0.5) 0.54 (0.52, 0.56) 0.5 (0.5, 0.5) 0.51 (0.51, 0.52) 0.53 (0.53, 0.53) 0.51 (0.51, 0.51)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.012 (0, 0.041) 0 (0, 0) 0.079 (0.021, 0.112) 0 (0, 0) 0 (0, 0) 0 (0, 0.112) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.578) 0 (0, 0.471) 0.395 (0.079, 0.712) 0 (0, 0)
PARPi count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 5 (5, 5) 2 (2, 2) 6 (6, 6) 1 (1, 1) 1 (1, 1) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 5 (5, 5) 1 (1, 1) 0 (0, 0) 1 (1, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0)
post_p 0.59 (0.59, 0.59) 0.51 (0.51, 0.51) 0.5 (0.5, 0.5) 0.53 (0.53, 0.53) 0.53 (0.53, 0.53) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.57) 0.53 (0.53, 0.53) NA (NA, NA) 0.58 (0.58, 0.58) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.085 (0.085, 0.085) 0 (0, 0) 0.151 (0.151, 0.151) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53- & AR- ARSi count 109 109 109 109
time 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18)
n 19 (15, 30) 4 (1, 8) 3 (1, 6) 3 (1, 5)
post_p 0.96 (0.84, 1) 0.59 (0.52, 0.76) 0.6 (0.51, 0.75) 0.54 (0.51, 0.61)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.027 (0.011, 0.05) 0.019 (0, 0.074) 0 (0, 0.08) 0 (0, 0.078)
Taxane_CT count 3 3 3 3
time 10 (8, 10) 10 (8, 10) 10 (8, 10) 10 (8, 10)
n 19 (13, 20) 3 (1, 5) 3 (1, 5) 4 (2, 5)
post_p 0.84 (0.79, 0.84) 0.65 (0.56, 0.69) 0.53 (0.51, 0.68) 0.56 (0.54, 0.56)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.047 (0.033, 0.079) 0 (0, 0) 0 (0, 0.077) 0 (0, 0)
Platinum_CT count 5 5 5 5
time 9 (7, 14) 9 (7, 14) 9 (7, 14) 9 (7, 14)
n 21 (15, 25) 3 (2, 4) 4 (2, 5) 3 (1, 4)
post_p 0.77 (0.74, 0.84) 0.57 (0.52, 0.63) 0.59 (0.54, 0.69) 0.56 (0.52, 0.66)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.079 (0.072, 0.087) 0.048 (0, 0.055) 0 (0, 0) 0 (0, 0.014)
PARPi count 3 3 3 3
time 9 (9, 17) 9 (9, 17) 9 (9, 17) 9 (9, 17)
n 21 (18, 22) 3 (2, 4) 3 (1, 8) 5 (3, 7)
post_p 0.76 (0.73, 0.8) 0.58 (0.54, 0.58) 0.54 (0.53, 0.79) 0.58 (0.57, 0.7)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.095 (0.077, 0.096) 0 (0, 0.14) 0 (0, 0.01) 0 (0, 0.037)
TP53+ ARSi count 1 1 1 1 1 1 1 1
time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
n 17 (17, 17) 5 (5, 5) 1 (1, 1) 1 (1, 1) 1 (1, 1) 4 (4, 4) 1 (1, 1) 0 (0, 0)
post_p 0.81 (0.81, 0.81) 0.57 (0.57, 0.57) 0.56 (0.56, 0.56) 0.54 (0.54, 0.54) 0.52 (0.52, 0.52) 0.62 (0.62, 0.62) 0.56 (0.56, 0.56) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.072 (0.072, 0.072) 0.059 (0.059, 0.059) 0 (0, 0) 0 (0, 0) 0.151 (0.151, 0.151) 0.07 (0.07, 0.07) 0 (0, 0) NA (NA, NA)
Taxane_CT count 18 18 18 18 18 18 18 18
time 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17) 13 (10, 17)
n 12 (8, 16) 8 (5, 11) 2 (1, 4) 2 (0, 4) 4 (0, 7) 4 (2, 7) 2 (0, 4) 4 (0, 5)
post_p 0.8 (0.71, 0.9) 0.88 (0.73, 0.93) 0.54 (0.51, 0.59) 0.57 (0.52, 0.69) 0.64 (0.54, 0.77) 0.75 (0.62, 0.9) 0.53 (0.51, 0.6) 0.54 (0.5, 0.67)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.076 (0.052, 0.134) 0.03 (0, 0.053) 0.068 (0, 0.204) 0 (0, 0.053) 0.112 (0, 0.149) 0 (0, 0.065) 0.057 (0, 0.09) 0.029 (0, 0.115)
Platinum_CT count 3 3 3 3 3 3 3 3
time 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14)
n 12 (11, 13) 6 (5, 8) 0 (0, 2) 3 (2, 3) 3 (1, 4) 2 (0, 4) 2 (1, 4) 1 (1, 2)
post_p 0.79 (0.74, 0.79) 0.74 (0.68, 0.84) 0.62 (0.62, 0.62) 0.59 (0.56, 0.63) 0.55 (0.54, 0.6) 0.54 (0.53, 0.55) 0.55 (0.55, 0.56) 0.63 (0.54, 0.63)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.1 (0.081, 0.109) 0.061 (0.047, 0.064) 0 (0, 0) 0 (0, 0) 0.07 (0.014, 0.099) 0.067 (0.062, 0.073) 0 (0, 0.044) 0 (0, 0)
PARPi count 4 4 4 4 4 4 4 4
time 12 (11, 14) 12 (11, 14) 12 (11, 14) 12 (11, 14) 12 (11, 14) 12 (11, 14) 12 (11, 14) 12 (11, 14)
n 10 (8, 14) 4 (4, 8) 2 (1, 2) 2 (1, 4) 2 (1, 4) 2 (1, 3) 2 (1, 3) 2 (1, 4)
post_p 0.8 (0.73, 0.84) 0.66 (0.57, 0.7) 0.54 (0.51, 0.6) 0.55 (0.51, 0.62) 0.68 (0.65, 0.77) 0.59 (0.57, 0.6) 0.61 (0.54, 0.64) 0.54 (0.51, 0.64)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.077 (0.052, 0.102) 0.094 (0.028, 0.095) 0 (0, 0.086) 0.021 (0, 0.085) 0 (0, 0.05) 0.05 (0, 0.105) 0 (0, 0.054) 0 (0, 0.081)
HRD+ Platinum_CT count 220 220 220 220 220 220 220 220
time 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34)
n 8 (3, 14) 8 (3, 15) 4 (2, 9) 4 (2, 10) 4 (2, 9) 4 (2, 9) 4 (2, 9) 4 (1, 10)
post_p 0.79 (0.59, 0.97) 0.73 (0.55, 0.89) 0.74 (0.55, 0.95) 0.66 (0.54, 0.85) 0.73 (0.55, 0.94) 0.68 (0.53, 0.89) 0.73 (0.55, 0.93) 0.71 (0.53, 0.89)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.03 (0, 0.06) 0.026 (0, 0.046) 0.029 (0, 0.077) 0.029 (0, 0.063) 0.028 (0, 0.081) 0.024 (0, 0.06) 0.027 (0, 0.063) 0.028 (0, 0.067)
PARPi count 195 195 195 195 195 195 195 195
time 23 (14, 34) 23 (14, 34) 23 (14, 34) 23 (14, 34) 23 (14, 34) 23 (14, 34) 23 (14, 34) 23 (14, 34)
n 8 (3, 14) 8 (3, 17) 4 (2, 10) 4 (2, 9) 4 (1, 8) 4 (2, 10) 5 (2, 9) 5 (2, 10)
post_p 0.8 (0.62, 0.97) 0.73 (0.53, 0.89) 0.77 (0.56, 0.95) 0.7 (0.53, 0.89) 0.74 (0.54, 0.94) 0.69 (0.54, 0.85) 0.74 (0.54, 0.93) 0.7 (0.53, 0.9)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.027 (0, 0.059) 0.027 (0, 0.051) 0.029 (0, 0.068) 0.026 (0, 0.055) 0.027 (0, 0.083) 0.024 (0, 0.061) 0.03 (0, 0.067) 0.026 (0, 0.058)
TEfus+ Taxane_CT count 111 111 111 111 111 111 111 111
time 16 (10, 31) 16 (10, 31) 16 (10, 31) 16 (10, 31) 16 (10, 31) 16 (10, 31) 16 (10, 31) 16 (10, 31)
n 5 (2, 12) 10 (5, 21) 5 (2, 13) 3 (1, 8) 4 (2, 9) 4 (2, 10) 4 (1, 8) 3 (1, 8)
post_p 0.71 (0.53, 0.91) 0.91 (0.72, 1) 0.62 (0.52, 0.84) 0.58 (0.52, 0.79) 0.7 (0.55, 0.95) 0.72 (0.56, 0.95) 0.58 (0.51, 0.8) 0.57 (0.51, 0.77)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.028 (0, 0.061) 0.029 (0, 0.058) 0.027 (0, 0.057) 0.019 (0, 0.068) 0.023 (0, 0.074) 0.021 (0, 0.068) 0.026 (0, 0.064) 0.035 (0, 0.083)
Platinum_CT count 2 2 2 2 2 2 2 2
time 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13)
n 4 (3, 5) 8 (6, 10) 2 (2, 3) 3 (2, 4) 4 (3, 4) 2 (1, 2) 2 (2, 3) 2 (1, 4)
post_p 0.67 (0.65, 0.69) 0.63 (0.58, 0.69) 0.56 (0.53, 0.6) 0.59 (0.58, 0.6) 0.62 (0.6, 0.65) 0.57 (0.56, 0.58) 0.74 (0.67, 0.82) 0.62 (0.61, 0.64)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.046 (0.039, 0.054) 0.087 (0.085, 0.09) 0 (0, 0) 0.022 (0.004, 0.04) 0.037 (0.007, 0.066) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PARPi count 2 2 2 2 2 2 2 2
time 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13)
n 2 (2, 3) 4 (4, 5) 6 (5, 8) 4 (3, 4) 3 (2, 4) 2 (1, 2) 4 (3, 5) 2 (1, 2)
post_p 0.55 (0.53, 0.57) 0.72 (0.71, 0.72) 0.62 (0.54, 0.69) 0.62 (0.61, 0.63) 0.62 (0.6, 0.64) 0.58 (0.57, 0.59) 0.6 (0.57, 0.63) 0.62 (0.61, 0.62)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.054 (0.037, 0.072) 0.053 (0.048, 0.058) 0.045 (0.028, 0.062) 0.028 (0.006, 0.051) 0.036 (0.007, 0.065) 0 (0, 0) 0.033 (0.007, 0.06) 0 (0, 0)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Taxane_CT count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3)
n 9 (9, 9) 1 (1, 1) 4 (4, 4) 1 (1, 1) 2 (2, 2) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 1 (1, 1) 1 (1, 1) 3 (3, 3) 1 (1, 1)
post_p 0.49 (0.49, 0.49) 0.5 (0.5, 0.5) 0.38 (0.38, 0.38) 0.47 (0.47, 0.47) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) 0.49 (0.49, 0.49)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.132 (0.132, 0.132) 0 (0, 0) 0.293 (0.293, 0.293) 0 (0, 0) 0.581 (0.581, 0.581) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.987 (0.987, 0.987) 0.115 (0.115, 0.115) 0 (0, 0)
TP53- & AR- ARSi count 1 1 1 1
time 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20)
n 35 (35, 35) 3 (3, 3) 4 (4, 4) 3 (3, 3)
post_p 0.4 (0.4, 0.4) 0.26 (0.26, 0.26) 0.47 (0.47, 0.47) 0.47 (0.47, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.068 (0.068, 0.068) 0.191 (0.191, 0.191) 0.106 (0.106, 0.106) 0.09 (0.09, 0.09)
Taxane_CT count 89 89 89 89
time 13 (9, 21) 13 (9, 21) 13 (9, 21) 13 (9, 21)
n 21 (16, 36) 3 (1, 8) 5 (2, 8) 4 (2, 9)
post_p 0.15 (0.02, 0.35) 0.45 (0.38, 0.5) 0.36 (0.12, 0.48) 0.45 (0.34, 0.49)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.141 (0.107, 0.213) 0.094 (0.058, 0.255) 0.141 (0.071, 0.267) 0.072 (0.038, 0.163)
Platinum_CT count 51 51 51 51
time 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18)
n 20 (14, 36) 4 (1, 9) 4 (1, 7) 4 (2, 8)
post_p 0.18 (0.02, 0.38) 0.36 (0.17, 0.44) 0.46 (0.33, 0.5) 0.44 (0.38, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.137 (0.108, 0.198) 0.191 (0.099, 0.409) 0.081 (0.033, 0.239) 0.065 (0.034, 0.219)
PARPi count 72 72 72 72
time 13 (9, 19) 13 (9, 19) 13 (9, 19) 13 (9, 19)
n 22 (15, 34) 4 (2, 8) 4 (1, 7) 4 (0, 8)
post_p 0.19 (0.03, 0.4) 0.36 (0.15, 0.46) 0.46 (0.38, 0.49) 0.45 (0.32, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.144 (0.107, 0.206) 0.176 (0.088, 0.357) 0.086 (0.048, 0.193) 0.077 (0.031, 0.22)
TP53+ ARSi count 219 219 219 219 219 219 219 219
time 18 (9, 31) 18 (9, 31) 18 (9, 31) 18 (9, 31) 18 (9, 31) 18 (9, 31) 18 (9, 31) 18 (9, 31)
n 17 (8, 32) 11 (5, 22) 3 (1, 8) 3 (0, 6) 5 (2, 9) 5 (1, 9) 3 (0, 7) 3 (1, 7)
post_p 0.37 (0.15, 0.49) 0.25 (0.05, 0.47) 0.4 (0.19, 0.48) 0.35 (0.18, 0.47) 0.42 (0.24, 0.48) 0.38 (0.14, 0.48) 0.37 (0.17, 0.48) 0.38 (0.16, 0.48)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.163 (0.127, 0.227) 0.152 (0.102, 0.273) 0.172 (0.082, 0.408) 0.164 (0.069, 0.37) 0.182 (0.112, 0.386) 0.167 (0.093, 0.358) 0.166 (0.092, 0.424) 0.167 (0.069, 0.421)
PARPi count 3 3 3 3 3 3 3 3
time 9 (8, 13) 9 (8, 13) 9 (8, 13) 9 (8, 13) 9 (8, 13) 9 (8, 13) 9 (8, 13) 9 (8, 13)
n 13 (8, 17) 9 (7, 14) 0 (0, 0) 0 (0, 3) 3 (1, 5) 3 (1, 4) 2 (0, 3) 1 (0, 2)
post_p 0.28 (0.2, 0.43) 0.23 (0.11, 0.38) NA (NA, NA) 0.49 (0.49, 0.49) 0.37 (0.35, 0.39) 0.41 (0.24, 0.47) 0.44 (0.42, 0.47) 0.43 (0.42, 0.45)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.211 (0.107, 0.302) 0.112 (0.107, 0.239) NA (NA, NA) 0.047 (0.047, 0.047) 0.334 (0.173, 0.496) 0.291 (0.149, 5.074) 0.136 (0.135, 0.137) 0.683 (0.644, 0.722)
HRD+ ARSi count 220 220 220 220 220 220 220 220
time 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32)
n 8 (3, 12) 6 (3, 12) 4 (1, 8) 3 (1, 7) 4 (2, 8) 4 (2, 8) 4 (2, 7) 3 (1, 7)
post_p 0.4 (0.2, 0.48) 0.36 (0.14, 0.46) 0.38 (0.19, 0.47) 0.36 (0.17, 0.46) 0.36 (0.18, 0.48) 0.34 (0.14, 0.46) 0.36 (0.16, 0.48) 0.35 (0.17, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.101 (0.069, 0.17) 0.085 (0.05, 0.155) 0.165 (0.092, 0.349) 0.157 (0.082, 0.378) 0.16 (0.09, 0.387) 0.159 (0.091, 0.36) 0.173 (0.091, 0.445) 0.159 (0.078, 0.368)
Taxane_CT count 32 32 32 32 32 32 32 32
time 18 (12, 27) 18 (12, 27) 18 (12, 27) 18 (12, 27) 18 (12, 27) 18 (12, 27) 18 (12, 27) 18 (12, 27)
n 5 (3, 11) 6 (3, 12) 4 (2, 6) 5 (1, 7) 4 (1, 7) 4 (2, 6) 4 (1, 7) 4 (2, 7)
post_p 0.3 (0.11, 0.43) 0.42 (0.29, 0.47) 0.35 (0.2, 0.48) 0.43 (0.31, 0.49) 0.42 (0.29, 0.48) 0.43 (0.27, 0.47) 0.34 (0.14, 0.45) 0.42 (0.3, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.137 (0.077, 0.285) 0.068 (0.048, 0.107) 0.174 (0.102, 0.324) 0.097 (0.055, 0.301) 0.136 (0.081, 0.217) 0.101 (0.068, 0.248) 0.172 (0.095, 0.573) 0.091 (0.059, 0.19)
TEfus+ ARSi count 155 155 155 155 155 155 155 155
time 20 (11, 31) 20 (11, 31) 20 (11, 31) 20 (11, 31) 20 (11, 31) 20 (11, 31) 20 (11, 31) 20 (11, 31)
n 5 (2, 12) 11 (5, 20) 6 (2, 11) 3 (1, 7) 5 (2, 11) 4 (2, 9) 4 (1, 8) 3 (1, 7)
post_p 0.45 (0.31, 0.49) 0.25 (0.05, 0.42) 0.4 (0.24, 0.48) 0.35 (0.2, 0.47) 0.34 (0.15, 0.47) 0.36 (0.14, 0.46) 0.36 (0.15, 0.46) 0.36 (0.19, 0.47)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.088 (0.057, 0.179) 0.146 (0.103, 0.234) 0.081 (0.045, 0.166) 0.162 (0.076, 0.347) 0.147 (0.09, 0.322) 0.159 (0.083, 0.384) 0.142 (0.071, 0.403) 0.16 (0.08, 0.428)
Platinum_CT count 4 4 4 4 4 4 4 4
time 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14)
n 4 (3, 6) 8 (7, 10) 4 (3, 5) 2 (0, 3) 3 (3, 4) 3 (3, 4) 2 (2, 3) 2 (0, 3)
post_p 0.41 (0.23, 0.48) 0.35 (0.32, 0.39) 0.44 (0.4, 0.47) 0.44 (0.38, 0.47) 0.4 (0.37, 0.43) 0.39 (0.34, 0.45) 0.43 (0.4, 0.48) 0.47 (0.46, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.203 (0.13, 0.316) 0.135 (0.101, 0.204) 0.063 (0.014, 0.105) 0.132 (0.078, 0.363) 0.237 (0.117, 0.409) 0.201 (0.119, 0.4) 0.161 (0.107, 0.195) 0.07 (0.014, 0.175)
PARPi count 10 10 10 10 10 10 10 10
time 19 (12, 26) 19 (12, 26) 19 (12, 26) 19 (12, 26) 19 (12, 26) 19 (12, 26) 19 (12, 26) 19 (12, 26)
n 6 (4, 9) 9 (6, 15) 4 (3, 9) 4 (0, 6) 6 (3, 9) 3 (1, 7) 4 (2, 7) 2 (2, 8)
post_p 0.27 (0.05, 0.42) 0.27 (0.04, 0.44) 0.44 (0.2, 0.48) 0.46 (0.42, 0.49) 0.36 (0.1, 0.41) 0.36 (0.3, 0.43) 0.47 (0.41, 0.49) 0.46 (0.33, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.185 (0.082, 0.289) 0.15 (0.109, 0.223) 0.057 (0.027, 0.15) 0.07 (0.02, 0.103) 0.136 (0.122, 0.23) 0.185 (0.148, 0.882) 0.09 (0.04, 0.184) 0.074 (0.026, 0.163)