Simulation scenario 10, CR phase

Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
all	param	scale = 0.138, shape = 1.05	scale = 0.102, shape = 1.05	scale = 0.103, shape = 1.05	scale = 0.11, shape = 1.05	scale = 0.11, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 9.6, median = 6.9	mean = 9.5, median = 6.8	mean = 8.9, median = 6.4	mean = 8.9, median = 6.4
	effect	af = 1, hr = 1	af = 1.35, hr = 0.73	af = 1.34, hr = 0.74	af = 1.25, hr = 0.79	af = 1.25, hr = 0.79
TP53- & AR-	param	scale = 0.138, shape = 1.05	scale = 0.048, shape = 1.05	scale = 0.114, shape = 1.05	scale = 0.113, shape = 1.05	scale = 0.113, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 20.5, median = 14.8	mean = 8.6, median = 6.2	mean = 8.7, median = 6.2	mean = 8.7, median = 6.2
	effect	af = 1, hr = 1	af = 2.89, hr = 0.33	af = 1.21, hr = 0.82	af = 1.22, hr = 0.81	af = 1.22, hr = 0.81
TP53+	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.095, shape = 1.05	scale = 0.111, shape = 1.05	scale = 0.111, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 10.3, median = 7.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.45, hr = 0.68	af = 1.24, hr = 0.8	af = 1.24, hr = 0.8
HRD+	param	scale = 0.138, shape = 1.05	scale = 0.116, shape = 1.05	scale = 0.095, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 8.5, median = 6.1	mean = 10.3, median = 7.4	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1.19, hr = 0.83	af = 1.45, hr = 0.68	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
TEfus+	param	scale = 0.138, shape = 1.05	scale = 0.118, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.1, shape = 1.05	scale = 0.1, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 8.3, median = 6	mean = 23.5, median = 16.9	mean = 9.8, median = 7.1	mean = 9.8, median = 7.1
	effect	af = 1, hr = 1	af = 1.17, hr = 0.85	af = 3.31, hr = 0.28	af = 1.38, hr = 0.71	af = 1.38, hr = 0.71

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	param	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.138, shape = 1.05	scale = 0.05, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 19.4, median = 14	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 2.73, hr = 0.35	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.138, shape = 1.05	scale = 0.076, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 12.9, median = 9.3	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1.82, hr = 0.53	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
-+-+	param	scale = 0.138, shape = 1.05	scale = 0.076, shape = 1.05	scale = 0.047, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 12.9, median = 9.3	mean = 21, median = 15.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1.82, hr = 0.53	af = 2.96, hr = 0.32	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
-++-	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
-+++	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.047, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 21, median = 15.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.96, hr = 0.32	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
+—	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
++-+	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.39, hr = 0.4	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
+++-	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24
++++	param	scale = 0.138, shape = 1.05	scale = 0.138, shape = 1.05	scale = 0.058, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05
	summary	mean = 7.1, median = 5.1	mean = 7.1, median = 5.1	mean = 17, median = 12.2	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 2.39, hr = 0.4	af = 3.86, hr = 0.24	af = 3.86, hr = 0.24

Errors and power

graduation (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 4 0 0 1 TP53- & AR- 109 3 5 3 TP53+ 1 18 3 4 HRD+ 0 0 220 195 TEfus+ 0 111 2 2

ARSi Taxane_CT Platinum_CT PARPi all 0.008 0.000 0.000 0.002 TP53- & AR- 0.218 0.006 0.010 0.006 TP53+ 0.002 0.036 0.006 0.008 HRD+ 0.000 0.000 0.440 0.390 TEfus+ 0.000 0.222 0.004 0.004

futility (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 0 1 0 0 TP53- & AR- 1 89 51 72 TP53+ 219 0 0 3 HRD+ 220 32 0 0 TEfus+ 155 0 4 10

ARSi Taxane_CT Platinum_CT PARPi all 0.000 0.002 0.000 0.000 TP53- & AR- 0.002 0.178 0.102 0.144 TP53+ 0.438 0.000 0.000 0.006 HRD+ 0.440 0.064 0.000 0.000 TEfus+ 0.310 0.000 0.008 0.020

max sample size (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 0 0 0 0 TP53- & AR- 3 5 7 4 TP53+ 0 12 10 13 HRD+ 0 0 0 0 TEfus+ 0 1 0 3

ARSi Taxane_CT Platinum_CT PARPi all 0.000 0.000 0.000 0.000 TP53- & AR- 0.006 0.010 0.014 0.008 TP53+ 0.000 0.024 0.020 0.026 HRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.002 0.000 0.006

Errors & power

The overall error was 0.044.
The corresponding errors separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.010       0.016       0.008       0.012 

The overall power was 0.79.
The corresponding power separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.218       0.222       0.440       0.390 

Median results at the end of the trial

By signature:

signature	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
all	graduation	0	4	0	0	1
	futility	0	0	1	0	0
	max_n	0	0	0	0	0
	n	268 (236, 306)	192 (132, 253)	242 (178, 285)	243 (190, 284)	240 (190, 283)
	n_unique	247 (217, 280)	176 (119, 232)	222 (163, 261)	224 (175, 260)	221 (174, 261)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	5 (4, 6)	3 (3, 3)	NA (NA, NA)	4 (4, 4)
	post_p	NA (NA, NA)	0.83 (0.23, 1)	0.84 (0.24, 0.99)	0.56 (0.1, 0.93)	0.56 (0.09, 0.93)
	rate	0.095 (0.086, 0.105)	0.084 (0.072, 0.1)	0.085 (0.076, 0.099)	0.093 (0.083, 0.105)	0.093 (0.083, 0.105)
TP53- & AR-	graduation	0	109	3	5	3
	futility	0	1	89	51	72
	max_n	0	3	5	7	4
	n	108 (89, 134)	86 (27, 111)	97 (32, 120)	96 (52, 123)	95 (40, 122)
	n_unique	99 (81, 124)	80 (25, 103)	89 (30, 112)	90 (49, 112)	88 (38, 112)
	time_trial	36 (36, 36)	36 (11, 36)	36 (13, 36)	36 (18, 36)	36 (15, 36)
	time_stop	NA (NA, NA)	11 (8, 19)	13 (8, 21)	12 (9, 18)	13 (9, 19)
	post_p	NA (NA, NA)	1 (0.96, 1)	0.07 (0, 0.41)	0.11 (0, 0.49)	0.09 (0, 0.49)
	rate	0.077 (0.065, 0.089)	0.043 (0.036, 0.053)	0.1 (0.083, 0.123)	0.096 (0.081, 0.118)	0.098 (0.081, 0.119)
TP53+	graduation	0	1	18	3	4
	futility	0	219	0	0	3
	max_n	0	0	12	10	13
	n	119 (101, 140)	86 (30, 115)	110 (81, 134)	111 (90, 131)	110 (89, 135)
	n_unique	109 (92, 129)	78 (28, 105)	100 (74, 123)	102 (83, 120)	102 (82, 124)
	time_trial	36 (36, 36)	36 (11, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	18 (9, 31)	13 (10, 17)	12 (9, 14)	11 (9, 14)
	post_p	NA (NA, NA)	0.05 (0, 0.31)	0.99 (0.74, 1)	0.78 (0.34, 0.98)	0.83 (0.35, 0.99)
	rate	0.112 (0.097, 0.127)	0.143 (0.122, 0.175)	0.078 (0.064, 0.096)	0.096 (0.082, 0.113)	0.095 (0.081, 0.113)
HRD+	graduation	0	0	0	220	195
	futility	0	220	32	0	0
	max_n	0	0	0	0	0
	n	81 (68, 100)	48 (27, 77)	71 (45, 96)	67 (28, 89)	69 (29, 89)
	n_unique	75 (62, 93)	43 (24, 69)	64 (40, 87)	60 (26, 82)	62 (27, 80)
	time_trial	36 (36, 36)	36 (17, 36)	36 (36, 36)	36 (16, 36)	36 (17, 36)
	time_stop	NA (NA, NA)	22 (14, 32)	18 (12, 27)	22 (14, 34)	23 (14, 34)
	post_p	NA (NA, NA)	0.18 (0.02, 0.6)	0.69 (0.22, 0.96)	1 (1, 1)	1 (1, 1)
	rate	0.103 (0.087, 0.123)	0.113 (0.089, 0.143)	0.083 (0.067, 0.105)	0.035 (0.027, 0.044)	0.035 (0.027, 0.045)
TEfus+	graduation	0	0	111	2	2
	futility	0	155	0	4	10
	max_n	0	0	1	0	3
	n	104 (86, 121)	66 (32, 98)	91 (34, 112)	92 (71, 115)	91 (67, 114)
	n_unique	95 (79, 111)	60 (29, 90)	82 (31, 102)	84 (63, 105)	83 (61, 105)
	time_trial	36 (36, 36)	36 (16, 36)	36 (15, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	20 (11, 31)	16 (10, 31)	12 (8, 14)	16 (9, 26)
	post_p	NA (NA, NA)	0.04 (0, 0.3)	1 (0.98, 1)	0.37 (0.06, 0.84)	0.39 (0.07, 0.82)
	rate	0.08 (0.067, 0.095)	0.111 (0.091, 0.137)	0.04 (0.032, 0.049)	0.083 (0.069, 0.102)	0.082 (0.069, 0.099)

By subgroup combinations:

subtype	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	graduation	0	114	93	56	76
	futility	0	0	0	0	0
	max_n	0	3	5	7	4
	n	64 (50, 83)	56 (19, 71)	58 (21, 75)	60 (35, 76)	59 (24, 75)
	n_unique	58 (45, 77)	53 (17, 68)	54 (20, 70)	57 (32, 72)	55 (23, 71)
	post_p	NA (NA, NA)	1 (0.99, 1)	0.01 (0, 0.08)	0.01 (0, 0.1)	0 (0, 0.09)
	rate	0.078 (0.061, 0.097)	0.034 (0.027, 0.045)	0.141 (0.116, 0.172)	0.139 (0.116, 0.166)	0.141 (0.116, 0.171)
—+	graduation	0	241	195	62	85
	futility	0	0	0	0	0
	max_n	0	3	6	7	7
	n	14 (9, 20)	9 (3, 16)	11 (3, 18)	13 (5, 19)	13 (4, 19)
	n_unique	12 (8, 19)	8 (2, 15)	10 (2, 16)	12 (5, 18)	11 (4, 18)
	post_p	NA (NA, NA)	0.68 (0.36, 0.93)	0.84 (0.52, 0.98)	0.08 (0.01, 0.31)	0.09 (0.01, 0.32)
	rate	0.056 (0.035, 0.09)	0.051 (0.028, 0.097)	0.038 (0.018, 0.069)	0.144 (0.097, 0.237)	0.144 (0.095, 0.232)
–+-	graduation	0	224	19	3	8
	futility	0	0	0	0	0
	max_n	0	0	12	10	13
	n	37 (28, 47)	31 (10, 40)	36 (28, 45)	37 (29, 45)	37 (28, 46)
	n_unique	34 (26, 43)	28 (10, 38)	34 (25, 42)	34 (26, 42)	34 (25, 43)
	post_p	NA (NA, NA)	0.48 (0.13, 0.85)	0.52 (0.13, 0.89)	0.49 (0.11, 0.87)	0.53 (0.14, 0.86)
	rate	0.139 (0.111, 0.178)	0.143 (0.113, 0.2)	0.14 (0.107, 0.176)	0.142 (0.113, 0.18)	0.14 (0.112, 0.179)
–++	graduation	0	296	118	8	18
	futility	0	0	0	0	0
	max_n	0	0	13	10	13
	n	26 (19, 34)	17 (6, 27)	23 (9, 32)	26 (19, 34)	25 (18, 34)
	n_unique	23 (17, 32)	16 (5, 25)	21 (8, 29)	24 (17, 32)	23 (16, 31)
	post_p	NA (NA, NA)	0.12 (0.02, 0.4)	0.99 (0.91, 1)	0.08 (0.01, 0.35)	0.08 (0.01, 0.37)
	rate	0.082 (0.061, 0.118)	0.146 (0.105, 0.21)	0.035 (0.021, 0.053)	0.139 (0.108, 0.179)	0.14 (0.108, 0.191)
-+–	graduation	0	303	116	264	257
	futility	0	0	0	0	0
	max_n	0	3	5	7	4
	n	15 (10, 22)	9 (3, 17)	13 (4, 20)	11 (4, 18)	11 (3, 18)
	n_unique	14 (9, 20)	8 (2, 16)	12 (4, 19)	10 (3, 16)	10 (3, 17)
	post_p	NA (NA, NA)	0.53 (0.2, 0.85)	0.16 (0.03, 0.42)	0.92 (0.68, 0.99)	0.92 (0.63, 0.99)
	rate	0.107 (0.071, 0.168)	0.078 (0.045, 0.149)	0.142 (0.094, 0.218)	0.036 (0.017, 0.064)	0.036 (0.02, 0.065)
-+-+	graduation	0	366	216	269	264
	futility	0	0	0	0	0
	max_n	0	3	6	7	6
	n	15 (10, 22)	7 (2, 17)	12 (3, 20)	12 (3, 19)	11 (3, 18)
	n_unique	14 (9, 21)	7 (2, 15)	11 (3, 18)	11 (3, 17)	10 (3, 17)
	post_p	NA (NA, NA)	0.35 (0.1, 0.62)	0.64 (0.31, 0.87)	0.76 (0.46, 0.94)	0.75 (0.43, 0.94)
	rate	0.072 (0.045, 0.113)	0.077 (0.046, 0.13)	0.046 (0.026, 0.079)	0.036 (0.018, 0.06)	0.035 (0.018, 0.065)
-++-	graduation	0	336	50	220	199
	futility	0	0	0	0	0
	max_n	0	0	12	10	11
	n	8 (5, 13)	5 (1, 10)	8 (4, 13)	6 (2, 11)	7 (3, 12)
	n_unique	8 (4, 12)	4 (1, 9)	7 (3, 11)	6 (2, 10)	6 (2, 11)
	post_p	NA (NA, NA)	0.32 (0.13, 0.57)	0.29 (0.1, 0.58)	0.86 (0.61, 0.98)	0.88 (0.61, 0.98)
	rate	0.143 (0.085, 0.249)	0.156 (0.083, 0.33)	0.144 (0.082, 0.238)	0.034 (0.014, 0.076)	0.036 (0.013, 0.075)
-+++	graduation	0	381	147	225	207
	futility	0	0	0	0	0
	max_n	0	0	13	10	12
	n	9 (5, 13)	4 (1, 9)	7 (2, 12)	7 (3, 11)	7 (3, 13)
	n_unique	8 (4, 12)	4 (1, 9)	6 (2, 11)	6 (2, 10)	6 (2, 11)
	post_p	NA (NA, NA)	0.24 (0.08, 0.42)	0.66 (0.38, 0.88)	0.72 (0.48, 0.91)	0.72 (0.49, 0.92)
	rate	0.095 (0.054, 0.164)	0.152 (0.085, 0.313)	0.044 (0.021, 0.092)	0.035 (0.015, 0.07)	0.037 (0.013, 0.071)
+—	graduation	0	4	1	0	1
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	12 (8, 17)	12 (7, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)
	n_unique	11 (7, 16)	11 (6, 15)	11 (7, 15)	11 (7, 15)	11 (7, 15)
	post_p	NA (NA, NA)	0.5 (0.17, 0.82)	0.51 (0.19, 0.84)	0.52 (0.18, 0.84)	0.51 (0.16, 0.81)
	rate	0.141 (0.097, 0.219)	0.142 (0.096, 0.215)	0.141 (0.095, 0.208)	0.141 (0.093, 0.213)	0.141 (0.094, 0.22)
+–+	graduation	0	159	112	6	13
	futility	0	0	0	0	0
	max_n	0	0	1	0	3
	n	10 (6, 15)	9 (4, 13)	9 (4, 14)	10 (5, 15)	10 (6, 15)
	n_unique	9 (5, 14)	8 (3, 12)	8 (3, 13)	9 (5, 14)	9 (5, 14)
	post_p	NA (NA, NA)	0.24 (0.07, 0.5)	0.93 (0.72, 0.99)	0.24 (0.05, 0.54)	0.26 (0.06, 0.6)
	rate	0.086 (0.047, 0.152)	0.147 (0.093, 0.246)	0.035 (0.013, 0.066)	0.145 (0.093, 0.229)	0.139 (0.088, 0.215)
+-+-	graduation	0	224	19	3	8
	futility	0	0	0	0	0
	max_n	0	0	12	10	13
	n	10 (6, 15)	8 (2, 12)	10 (5, 15)	10 (6, 14)	10 (5, 15)
	n_unique	9 (5, 13)	7 (2, 11)	9 (5, 13)	9 (6, 13)	9 (5, 13)
	post_p	NA (NA, NA)	0.48 (0.21, 0.81)	0.51 (0.21, 0.8)	0.48 (0.2, 0.81)	0.48 (0.18, 0.83)
	rate	0.143 (0.094, 0.227)	0.152 (0.095, 0.279)	0.143 (0.094, 0.222)	0.146 (0.091, 0.227)	0.148 (0.087, 0.236)
+-++	graduation	0	296	118	8	18
	futility	0	0	0	0	0
	max_n	0	0	13	10	13
	n	11 (6, 15)	7 (2, 12)	9 (3, 14)	10 (6, 15)	10 (6, 15)
	n_unique	10 (6, 14)	6 (2, 11)	8 (3, 13)	9 (6, 14)	9 (5, 14)
	post_p	NA (NA, NA)	0.27 (0.08, 0.53)	0.94 (0.72, 1)	0.24 (0.05, 0.53)	0.25 (0.05, 0.55)
	rate	0.088 (0.048, 0.148)	0.156 (0.094, 0.293)	0.035 (0.016, 0.065)	0.144 (0.094, 0.232)	0.144 (0.091, 0.23)
++–	graduation	0	224	33	220	196
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	8 (4, 12)	6 (2, 11)	8 (4, 12)	6 (3, 11)	6 (3, 11)
	n_unique	7 (3, 11)	5 (2, 10)	7 (3, 12)	6 (2, 10)	6 (2, 10)
	post_p	NA (NA, NA)	0.28 (0.1, 0.57)	0.29 (0.1, 0.55)	0.88 (0.64, 0.98)	0.86 (0.63, 0.98)
	rate	0.148 (0.084, 0.251)	0.154 (0.084, 0.291)	0.14 (0.083, 0.241)	0.035 (0.012, 0.073)	0.036 (0.013, 0.071)
++-+	graduation	0	304	142	225	206
	futility	0	0	0	0	0
	max_n	0	0	1	0	2
	n	8 (5, 13)	5 (2, 10)	7 (2, 12)	7 (3, 12)	7 (2, 11)
	n_unique	8 (4, 12)	5 (1, 9)	6 (2, 11)	6 (2, 10)	6 (2, 10)
	post_p	NA (NA, NA)	0.24 (0.07, 0.43)	0.59 (0.3, 0.84)	0.77 (0.51, 0.94)	0.77 (0.52, 0.93)
	rate	0.104 (0.055, 0.185)	0.147 (0.086, 0.305)	0.06 (0.026, 0.114)	0.033 (0.013, 0.07)	0.036 (0.011, 0.069)
+++-	graduation	0	336	50	220	199
	futility	0	0	0	0	0
	max_n	0	0	12	10	11
	n	8 (5, 13)	5 (1, 9)	8 (4, 13)	7 (2, 11)	7 (3, 11)
	n_unique	8 (4, 12)	4 (1, 9)	7 (3, 11)	6 (2, 10)	6 (3, 10)
	post_p	NA (NA, NA)	0.31 (0.11, 0.55)	0.29 (0.1, 0.55)	0.88 (0.63, 0.98)	0.86 (0.63, 0.98)
	rate	0.141 (0.082, 0.239)	0.156 (0.089, 0.355)	0.142 (0.086, 0.261)	0.034 (0.013, 0.069)	0.035 (0.014, 0.07)
++++	graduation	0	381	147	225	207
	futility	0	0	0	0	0
	max_n	0	0	13	10	12
	n	9 (5, 13)	4 (1, 10)	7 (2, 13)	7 (3, 12)	7 (3, 12)
	n_unique	8 (5, 12)	4 (1, 8)	6 (2, 11)	6 (2, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.28 (0.09, 0.47)	0.57 (0.3, 0.82)	0.76 (0.5, 0.94)	0.78 (0.5, 0.94)
	rate	0.104 (0.059, 0.176)	0.148 (0.078, 0.323)	0.058 (0.03, 0.118)	0.036 (0.014, 0.072)	0.033 (0.012, 0.071)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	4			1
	time_stop	5 (4, 6)			4 (4, 4)
	n_trt	32 (27, 39)			25 (25, 25)
	n_control	34 (22, 44)			22 (22, 22)
	post_p	0.96 (0.9, 0.98)			0.9 (0.9, 0.9)
	order	1 (1, 1)			1 (1, 1)
TP53- & AR-	count	109	3	5	3
	time_stop	11 (8, 18)	10 (8, 10)	9 (7, 14)	9 (9, 17)
	n_trt	27 (25, 43)	26 (25, 28)	30 (26, 34)	30 (28, 38)
	n_control	29 (20, 50)	26 (16, 28)	21 (18, 34)	31 (25, 52)
	post_p	0.97 (0.89, 1)	0.87 (0.86, 0.96)	0.88 (0.86, 0.91)	0.89 (0.88, 0.96)
	order	1 (1, 2)	1 (1, 1)	1 (1, 1.6)	1 (1, 1.8)
TP53+	count	1	18	3	4
	time_stop	13 (13, 13)	13 (10, 17)	12 (9, 14)	12 (11, 14)
	n_trt	30 (30, 30)	36 (27, 47)	28 (26, 37)	28 (26, 35)
	n_control	39 (39, 39)	38 (24, 54)	32 (32, 46)	38 (26, 45)
	post_p	0.91 (0.91, 0.91)	0.99 (0.94, 1)	0.94 (0.9, 0.96)	0.97 (0.92, 0.99)
	order	1 (1, 1)	1 (1, 2)	2 (1.2, 2)	2 (1.3, 2.7)
HRD+	count			220	195
	time_stop			22 (14, 34)	23 (14, 34)
	n_trt			40 (26, 77)	43 (26, 78)
	n_control			46 (25, 77)	47 (26, 78)
	post_p			1 (0.98, 1)	1 (0.98, 1)
	order			1 (1, 3)	2 (1, 3)
TEfus+	count		111	2	2
	time_stop		16 (10, 31)	12 (12, 13)	11 (9, 13)
	n_trt		37 (25, 79)	27 (25, 29)	27 (26, 28)
	n_control		42 (23, 84)	34 (28, 40)	30 (28, 32)
	post_p		1 (0.96, 1)	0.97 (0.96, 0.98)	0.98 (0.96, 0.99)
	order		1 (1, 2)	1 (1, 1)	1 (1, 1)

Futility:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count		1
	time_stop		3 (3, 3)
	n_trt		25 (25, 25)
	n_control		20 (20, 20)
	post_p		0.21 (0.21, 0.21)
	order		1 (1, 1)
TP53- & AR-	count	1	89	51	72
	time_stop	20 (20, 20)	13 (9, 21)	12 (10, 18)	13 (9, 19)
	n_trt	45 (45, 45)	32 (26, 56)	30 (25, 52)	33 (25, 56)
	n_control	56 (56, 56)	35 (19, 60)	33 (22, 47)	33 (19, 60)
	post_p	0.18 (0.18, 0.18)	0.1 (0, 0.26)	0.1 (0.01, 0.22)	0.1 (0.01, 0.23)
	order	3 (3, 3)	1 (1, 2)	1 (1, 2)	1 (1, 2)
TP53+	count	219			3
	time_stop	18 (9, 31)			9 (8, 13)
	n_trt	51 (27, 90)			26 (25, 42)
	n_control	51 (23, 97)			22 (20, 40)
	post_p	0.05 (0.01, 0.18)			0.15 (0.12, 0.17)
	order	1 (1, 3)			1 (1, 1.8)
HRD+	count	220	32
	time_stop	22 (14, 32)	18 (12, 27)
	n_trt	36 (25, 57)	32 (26, 59)
	n_control	42 (24, 66)	36 (21, 57)
	post_p	0.07 (0.01, 0.22)	0.11 (0.02, 0.26)
	order	2 (1, 3)	2 (1, 3)
TEfus+	count	155		4	10
	time_stop	20 (11, 31)		10 (8, 14)	19 (12, 26)
	n_trt	43 (26, 70)		30 (27, 31)	39 (27, 56)
	n_control	50 (26, 87)		24 (21, 30)	52 (27, 73)
	post_p	0.03 (0, 0.14)		0.1 (0.05, 0.15)	0.08 (0.04, 0.16)
	order	2 (1, 3)		2 (1.3, 2)	2 (1, 2.1)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)
		n	10 (8, 12)	1 (1, 1)	5 (3, 7)	4 (2, 5)	2 (1, 3)	2 (1, 4)	0 (0, 1)	0 (0, 1)	2 (2, 3)	0 (0, 2)	0 (0, 1)	1 (0, 2)	1 (0, 1)	1 (0, 2)	0 (0, 2)	0 (0, 1)
		post_p	0.7 (0.58, 0.79)	0.53 (0.52, 0.55)	0.69 (0.61, 0.71)	0.58 (0.55, 0.77)	0.54 (0.54, 0.54)	0.53 (0.51, 0.53)	NA (NA, NA)	0.54 (0.54, 0.54)	0.54 (0.52, 0.62)	0.54 (0.54, 0.54)	0.5 (0.5, 0.5)	0.54 (0.52, 0.56)	0.5 (0.5, 0.5)	0.51 (0.51, 0.52)	0.53 (0.53, 0.53)	0.51 (0.51, 0.51)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.012 (0, 0.041)	0 (0, 0)	0.079 (0.021, 0.112)	0 (0, 0)	0 (0, 0)	0 (0, 0.112)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.578)	0 (0, 0.471)	0.395 (0.079, 0.712)	0 (0, 0)
	PARPi	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	5 (5, 5)	2 (2, 2)	6 (6, 6)	1 (1, 1)	1 (1, 1)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	5 (5, 5)	1 (1, 1)	0 (0, 0)	1 (1, 1)	1 (1, 1)	0 (0, 0)	0 (0, 0)
		post_p	0.59 (0.59, 0.59)	0.51 (0.51, 0.51)	0.5 (0.5, 0.5)	0.53 (0.53, 0.53)	0.53 (0.53, 0.53)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.57 (0.57, 0.57)	0.53 (0.53, 0.53)	NA (NA, NA)	0.58 (0.58, 0.58)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.085 (0.085, 0.085)	0 (0, 0)	0.151 (0.151, 0.151)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53- & AR-	ARSi	count	109	109			109	109
		time	11 (8, 18)	11 (8, 18)			11 (8, 18)	11 (8, 18)
		n	19 (15, 30)	4 (1, 8)			3 (1, 6)	3 (1, 5)
		post_p	0.96 (0.84, 1)	0.59 (0.52, 0.76)			0.6 (0.51, 0.75)	0.54 (0.51, 0.61)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.027 (0.011, 0.05)	0.019 (0, 0.074)			0 (0, 0.08)	0 (0, 0.078)
	Taxane_CT	count	3	3			3	3
		time	10 (8, 10)	10 (8, 10)			10 (8, 10)	10 (8, 10)
		n	19 (13, 20)	3 (1, 5)			3 (1, 5)	4 (2, 5)
		post_p	0.84 (0.79, 0.84)	0.65 (0.56, 0.69)			0.53 (0.51, 0.68)	0.56 (0.54, 0.56)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.047 (0.033, 0.079)	0 (0, 0)			0 (0, 0.077)	0 (0, 0)
	Platinum_CT	count	5	5			5	5
		time	9 (7, 14)	9 (7, 14)			9 (7, 14)	9 (7, 14)
		n	21 (15, 25)	3 (2, 4)			4 (2, 5)	3 (1, 4)
		post_p	0.77 (0.74, 0.84)	0.57 (0.52, 0.63)			0.59 (0.54, 0.69)	0.56 (0.52, 0.66)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.079 (0.072, 0.087)	0.048 (0, 0.055)			0 (0, 0)	0 (0, 0.014)
	PARPi	count	3	3			3	3
		time	9 (9, 17)	9 (9, 17)			9 (9, 17)	9 (9, 17)
		n	21 (18, 22)	3 (2, 4)			3 (1, 8)	5 (3, 7)
		post_p	0.76 (0.73, 0.8)	0.58 (0.54, 0.58)			0.54 (0.53, 0.79)	0.58 (0.57, 0.7)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.095 (0.077, 0.096)	0 (0, 0.14)			0 (0, 0.01)	0 (0, 0.037)
TP53+	ARSi	count			1	1			1	1			1	1			1	1
		time			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)
		n			17 (17, 17)	5 (5, 5)			1 (1, 1)	1 (1, 1)			1 (1, 1)	4 (4, 4)			1 (1, 1)	0 (0, 0)
		post_p			0.81 (0.81, 0.81)	0.57 (0.57, 0.57)			0.56 (0.56, 0.56)	0.54 (0.54, 0.54)			0.52 (0.52, 0.52)	0.62 (0.62, 0.62)			0.56 (0.56, 0.56)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.072 (0.072, 0.072)	0.059 (0.059, 0.059)			0 (0, 0)	0 (0, 0)			0.151 (0.151, 0.151)	0.07 (0.07, 0.07)			0 (0, 0)	NA (NA, NA)
	Taxane_CT	count			18	18			18	18			18	18			18	18
		time			13 (10, 17)	13 (10, 17)			13 (10, 17)	13 (10, 17)			13 (10, 17)	13 (10, 17)			13 (10, 17)	13 (10, 17)
		n			12 (8, 16)	8 (5, 11)			2 (1, 4)	2 (0, 4)			4 (0, 7)	4 (2, 7)			2 (0, 4)	4 (0, 5)
		post_p			0.8 (0.71, 0.9)	0.88 (0.73, 0.93)			0.54 (0.51, 0.59)	0.57 (0.52, 0.69)			0.64 (0.54, 0.77)	0.75 (0.62, 0.9)			0.53 (0.51, 0.6)	0.54 (0.5, 0.67)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.076 (0.052, 0.134)	0.03 (0, 0.053)			0.068 (0, 0.204)	0 (0, 0.053)			0.112 (0, 0.149)	0 (0, 0.065)			0.057 (0, 0.09)	0.029 (0, 0.115)
	Platinum_CT	count			3	3			3	3			3	3			3	3
		time			12 (9, 14)	12 (9, 14)			12 (9, 14)	12 (9, 14)			12 (9, 14)	12 (9, 14)			12 (9, 14)	12 (9, 14)
		n			12 (11, 13)	6 (5, 8)			0 (0, 2)	3 (2, 3)			3 (1, 4)	2 (0, 4)			2 (1, 4)	1 (1, 2)
		post_p			0.79 (0.74, 0.79)	0.74 (0.68, 0.84)			0.62 (0.62, 0.62)	0.59 (0.56, 0.63)			0.55 (0.54, 0.6)	0.54 (0.53, 0.55)			0.55 (0.55, 0.56)	0.63 (0.54, 0.63)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.1 (0.081, 0.109)	0.061 (0.047, 0.064)			0 (0, 0)	0 (0, 0)			0.07 (0.014, 0.099)	0.067 (0.062, 0.073)			0 (0, 0.044)	0 (0, 0)
	PARPi	count			4	4			4	4			4	4			4	4
		time			12 (11, 14)	12 (11, 14)			12 (11, 14)	12 (11, 14)			12 (11, 14)	12 (11, 14)			12 (11, 14)	12 (11, 14)
		n			10 (8, 14)	4 (4, 8)			2 (1, 2)	2 (1, 4)			2 (1, 4)	2 (1, 3)			2 (1, 3)	2 (1, 4)
		post_p			0.8 (0.73, 0.84)	0.66 (0.57, 0.7)			0.54 (0.51, 0.6)	0.55 (0.51, 0.62)			0.68 (0.65, 0.77)	0.59 (0.57, 0.6)			0.61 (0.54, 0.64)	0.54 (0.51, 0.64)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.077 (0.052, 0.102)	0.094 (0.028, 0.095)			0 (0, 0.086)	0.021 (0, 0.085)			0 (0, 0.05)	0.05 (0, 0.105)			0 (0, 0.054)	0 (0, 0.081)
HRD+	Platinum_CT	count					220	220	220	220					220	220	220	220
		time					22 (14, 34)	22 (14, 34)	22 (14, 34)	22 (14, 34)					22 (14, 34)	22 (14, 34)	22 (14, 34)	22 (14, 34)
		n					8 (3, 14)	8 (3, 15)	4 (2, 9)	4 (2, 10)					4 (2, 9)	4 (2, 9)	4 (2, 9)	4 (1, 10)
		post_p					0.79 (0.59, 0.97)	0.73 (0.55, 0.89)	0.74 (0.55, 0.95)	0.66 (0.54, 0.85)					0.73 (0.55, 0.94)	0.68 (0.53, 0.89)	0.73 (0.55, 0.93)	0.71 (0.53, 0.89)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.03 (0, 0.06)	0.026 (0, 0.046)	0.029 (0, 0.077)	0.029 (0, 0.063)					0.028 (0, 0.081)	0.024 (0, 0.06)	0.027 (0, 0.063)	0.028 (0, 0.067)
	PARPi	count					195	195	195	195					195	195	195	195
		time					23 (14, 34)	23 (14, 34)	23 (14, 34)	23 (14, 34)					23 (14, 34)	23 (14, 34)	23 (14, 34)	23 (14, 34)
		n					8 (3, 14)	8 (3, 17)	4 (2, 10)	4 (2, 9)					4 (1, 8)	4 (2, 10)	5 (2, 9)	5 (2, 10)
		post_p					0.8 (0.62, 0.97)	0.73 (0.53, 0.89)	0.77 (0.56, 0.95)	0.7 (0.53, 0.89)					0.74 (0.54, 0.94)	0.69 (0.54, 0.85)	0.74 (0.54, 0.93)	0.7 (0.53, 0.9)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.027 (0, 0.059)	0.027 (0, 0.051)	0.029 (0, 0.068)	0.026 (0, 0.055)					0.027 (0, 0.083)	0.024 (0, 0.061)	0.03 (0, 0.067)	0.026 (0, 0.058)
TEfus+	Taxane_CT	count		111		111		111		111		111		111		111		111
		time		16 (10, 31)		16 (10, 31)		16 (10, 31)		16 (10, 31)		16 (10, 31)		16 (10, 31)		16 (10, 31)		16 (10, 31)
		n		5 (2, 12)		10 (5, 21)		5 (2, 13)		3 (1, 8)		4 (2, 9)		4 (2, 10)		4 (1, 8)		3 (1, 8)
		post_p		0.71 (0.53, 0.91)		0.91 (0.72, 1)		0.62 (0.52, 0.84)		0.58 (0.52, 0.79)		0.7 (0.55, 0.95)		0.72 (0.56, 0.95)		0.58 (0.51, 0.8)		0.57 (0.51, 0.77)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.028 (0, 0.061)		0.029 (0, 0.058)		0.027 (0, 0.057)		0.019 (0, 0.068)		0.023 (0, 0.074)		0.021 (0, 0.068)		0.026 (0, 0.064)		0.035 (0, 0.083)
	Platinum_CT	count		2		2		2		2		2		2		2		2
		time		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)
		n		4 (3, 5)		8 (6, 10)		2 (2, 3)		3 (2, 4)		4 (3, 4)		2 (1, 2)		2 (2, 3)		2 (1, 4)
		post_p		0.67 (0.65, 0.69)		0.63 (0.58, 0.69)		0.56 (0.53, 0.6)		0.59 (0.58, 0.6)		0.62 (0.6, 0.65)		0.57 (0.56, 0.58)		0.74 (0.67, 0.82)		0.62 (0.61, 0.64)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.046 (0.039, 0.054)		0.087 (0.085, 0.09)		0 (0, 0)		0.022 (0.004, 0.04)		0.037 (0.007, 0.066)		0 (0, 0)		0 (0, 0)		0 (0, 0)
	PARPi	count		2		2		2		2		2		2		2		2
		time		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)		11 (9, 13)
		n		2 (2, 3)		4 (4, 5)		6 (5, 8)		4 (3, 4)		3 (2, 4)		2 (1, 2)		4 (3, 5)		2 (1, 2)
		post_p		0.55 (0.53, 0.57)		0.72 (0.71, 0.72)		0.62 (0.54, 0.69)		0.62 (0.61, 0.63)		0.62 (0.6, 0.64)		0.58 (0.57, 0.59)		0.6 (0.57, 0.63)		0.62 (0.61, 0.62)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.054 (0.037, 0.072)		0.053 (0.048, 0.058)		0.045 (0.028, 0.062)		0.028 (0.006, 0.051)		0.036 (0.007, 0.065)		0 (0, 0)		0.033 (0.007, 0.06)		0 (0, 0)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Taxane_CT	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)
		n	9 (9, 9)	1 (1, 1)	4 (4, 4)	1 (1, 1)	2 (2, 2)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	1 (1, 1)	1 (1, 1)	3 (3, 3)	1 (1, 1)
		post_p	0.49 (0.49, 0.49)	0.5 (0.5, 0.5)	0.38 (0.38, 0.38)	0.47 (0.47, 0.47)	0.43 (0.43, 0.43)	NA (NA, NA)	NA (NA, NA)	0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)	0.49 (0.49, 0.49)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.132 (0.132, 0.132)	0 (0, 0)	0.293 (0.293, 0.293)	0 (0, 0)	0.581 (0.581, 0.581)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.987 (0.987, 0.987)	0.115 (0.115, 0.115)	0 (0, 0)
TP53- & AR-	ARSi	count	1	1			1	1
		time	20 (20, 20)	20 (20, 20)			20 (20, 20)	20 (20, 20)
		n	35 (35, 35)	3 (3, 3)			4 (4, 4)	3 (3, 3)
		post_p	0.4 (0.4, 0.4)	0.26 (0.26, 0.26)			0.47 (0.47, 0.47)	0.47 (0.47, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.068 (0.068, 0.068)	0.191 (0.191, 0.191)			0.106 (0.106, 0.106)	0.09 (0.09, 0.09)
	Taxane_CT	count	89	89			89	89
		time	13 (9, 21)	13 (9, 21)			13 (9, 21)	13 (9, 21)
		n	21 (16, 36)	3 (1, 8)			5 (2, 8)	4 (2, 9)
		post_p	0.15 (0.02, 0.35)	0.45 (0.38, 0.5)			0.36 (0.12, 0.48)	0.45 (0.34, 0.49)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.141 (0.107, 0.213)	0.094 (0.058, 0.255)			0.141 (0.071, 0.267)	0.072 (0.038, 0.163)
	Platinum_CT	count	51	51			51	51
		time	12 (10, 18)	12 (10, 18)			12 (10, 18)	12 (10, 18)
		n	20 (14, 36)	4 (1, 9)			4 (1, 7)	4 (2, 8)
		post_p	0.18 (0.02, 0.38)	0.36 (0.17, 0.44)			0.46 (0.33, 0.5)	0.44 (0.38, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.137 (0.108, 0.198)	0.191 (0.099, 0.409)			0.081 (0.033, 0.239)	0.065 (0.034, 0.219)
	PARPi	count	72	72			72	72
		time	13 (9, 19)	13 (9, 19)			13 (9, 19)	13 (9, 19)
		n	22 (15, 34)	4 (2, 8)			4 (1, 7)	4 (0, 8)
		post_p	0.19 (0.03, 0.4)	0.36 (0.15, 0.46)			0.46 (0.38, 0.49)	0.45 (0.32, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.144 (0.107, 0.206)	0.176 (0.088, 0.357)			0.086 (0.048, 0.193)	0.077 (0.031, 0.22)
TP53+	ARSi	count			219	219			219	219			219	219			219	219
		time			18 (9, 31)	18 (9, 31)			18 (9, 31)	18 (9, 31)			18 (9, 31)	18 (9, 31)			18 (9, 31)	18 (9, 31)
		n			17 (8, 32)	11 (5, 22)			3 (1, 8)	3 (0, 6)			5 (2, 9)	5 (1, 9)			3 (0, 7)	3 (1, 7)
		post_p			0.37 (0.15, 0.49)	0.25 (0.05, 0.47)			0.4 (0.19, 0.48)	0.35 (0.18, 0.47)			0.42 (0.24, 0.48)	0.38 (0.14, 0.48)			0.37 (0.17, 0.48)	0.38 (0.16, 0.48)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.163 (0.127, 0.227)	0.152 (0.102, 0.273)			0.172 (0.082, 0.408)	0.164 (0.069, 0.37)			0.182 (0.112, 0.386)	0.167 (0.093, 0.358)			0.166 (0.092, 0.424)	0.167 (0.069, 0.421)
	PARPi	count			3	3			3	3			3	3			3	3
		time			9 (8, 13)	9 (8, 13)			9 (8, 13)	9 (8, 13)			9 (8, 13)	9 (8, 13)			9 (8, 13)	9 (8, 13)
		n			13 (8, 17)	9 (7, 14)			0 (0, 0)	0 (0, 3)			3 (1, 5)	3 (1, 4)			2 (0, 3)	1 (0, 2)
		post_p			0.28 (0.2, 0.43)	0.23 (0.11, 0.38)			NA (NA, NA)	0.49 (0.49, 0.49)			0.37 (0.35, 0.39)	0.41 (0.24, 0.47)			0.44 (0.42, 0.47)	0.43 (0.42, 0.45)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.211 (0.107, 0.302)	0.112 (0.107, 0.239)			NA (NA, NA)	0.047 (0.047, 0.047)			0.334 (0.173, 0.496)	0.291 (0.149, 5.074)			0.136 (0.135, 0.137)	0.683 (0.644, 0.722)
HRD+	ARSi	count					220	220	220	220					220	220	220	220
		time					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)
		n					8 (3, 12)	6 (3, 12)	4 (1, 8)	3 (1, 7)					4 (2, 8)	4 (2, 8)	4 (2, 7)	3 (1, 7)
		post_p					0.4 (0.2, 0.48)	0.36 (0.14, 0.46)	0.38 (0.19, 0.47)	0.36 (0.17, 0.46)					0.36 (0.18, 0.48)	0.34 (0.14, 0.46)	0.36 (0.16, 0.48)	0.35 (0.17, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.101 (0.069, 0.17)	0.085 (0.05, 0.155)	0.165 (0.092, 0.349)	0.157 (0.082, 0.378)					0.16 (0.09, 0.387)	0.159 (0.091, 0.36)	0.173 (0.091, 0.445)	0.159 (0.078, 0.368)
	Taxane_CT	count					32	32	32	32					32	32	32	32
		time					18 (12, 27)	18 (12, 27)	18 (12, 27)	18 (12, 27)					18 (12, 27)	18 (12, 27)	18 (12, 27)	18 (12, 27)
		n					5 (3, 11)	6 (3, 12)	4 (2, 6)	5 (1, 7)					4 (1, 7)	4 (2, 6)	4 (1, 7)	4 (2, 7)
		post_p					0.3 (0.11, 0.43)	0.42 (0.29, 0.47)	0.35 (0.2, 0.48)	0.43 (0.31, 0.49)					0.42 (0.29, 0.48)	0.43 (0.27, 0.47)	0.34 (0.14, 0.45)	0.42 (0.3, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.137 (0.077, 0.285)	0.068 (0.048, 0.107)	0.174 (0.102, 0.324)	0.097 (0.055, 0.301)					0.136 (0.081, 0.217)	0.101 (0.068, 0.248)	0.172 (0.095, 0.573)	0.091 (0.059, 0.19)
TEfus+	ARSi	count		155		155		155		155		155		155		155		155
		time		20 (11, 31)		20 (11, 31)		20 (11, 31)		20 (11, 31)		20 (11, 31)		20 (11, 31)		20 (11, 31)		20 (11, 31)
		n		5 (2, 12)		11 (5, 20)		6 (2, 11)		3 (1, 7)		5 (2, 11)		4 (2, 9)		4 (1, 8)		3 (1, 7)
		post_p		0.45 (0.31, 0.49)		0.25 (0.05, 0.42)		0.4 (0.24, 0.48)		0.35 (0.2, 0.47)		0.34 (0.15, 0.47)		0.36 (0.14, 0.46)		0.36 (0.15, 0.46)		0.36 (0.19, 0.47)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.088 (0.057, 0.179)		0.146 (0.103, 0.234)		0.081 (0.045, 0.166)		0.162 (0.076, 0.347)		0.147 (0.09, 0.322)		0.159 (0.083, 0.384)		0.142 (0.071, 0.403)		0.16 (0.08, 0.428)
	Platinum_CT	count		4		4		4		4		4		4		4		4
		time		10 (8, 14)		10 (8, 14)		10 (8, 14)		10 (8, 14)		10 (8, 14)		10 (8, 14)		10 (8, 14)		10 (8, 14)
		n		4 (3, 6)		8 (7, 10)		4 (3, 5)		2 (0, 3)		3 (3, 4)		3 (3, 4)		2 (2, 3)		2 (0, 3)
		post_p		0.41 (0.23, 0.48)		0.35 (0.32, 0.39)		0.44 (0.4, 0.47)		0.44 (0.38, 0.47)		0.4 (0.37, 0.43)		0.39 (0.34, 0.45)		0.43 (0.4, 0.48)		0.47 (0.46, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.203 (0.13, 0.316)		0.135 (0.101, 0.204)		0.063 (0.014, 0.105)		0.132 (0.078, 0.363)		0.237 (0.117, 0.409)		0.201 (0.119, 0.4)		0.161 (0.107, 0.195)		0.07 (0.014, 0.175)
	PARPi	count		10		10		10		10		10		10		10		10
		time		19 (12, 26)		19 (12, 26)		19 (12, 26)		19 (12, 26)		19 (12, 26)		19 (12, 26)		19 (12, 26)		19 (12, 26)
		n		6 (4, 9)		9 (6, 15)		4 (3, 9)		4 (0, 6)		6 (3, 9)		3 (1, 7)		4 (2, 7)		2 (2, 8)
		post_p		0.27 (0.05, 0.42)		0.27 (0.04, 0.44)		0.44 (0.2, 0.48)		0.46 (0.42, 0.49)		0.36 (0.1, 0.41)		0.36 (0.3, 0.43)		0.47 (0.41, 0.49)		0.46 (0.33, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.185 (0.082, 0.289)		0.15 (0.109, 0.223)		0.057 (0.027, 0.15)		0.07 (0.02, 0.103)		0.136 (0.122, 0.23)		0.185 (0.148, 0.882)		0.09 (0.04, 0.184)		0.074 (0.026, 0.163)